FAM134B 在 ER 自噬和疾病中的关键作用。
Critical roles of FAM134B in ER-phagy and diseases.
机构信息
Hubei Key Laboratory of Hepato-Pancreato-Biliary Diseases; Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Clinical Medicine Research Center for Hepatic Surgery of Hubei Province; Key Laboratory of Organ Transplantation, Ministry of Education and Ministry of Public Health, Wuhan, Hubei, 430030, P.R. China.
出版信息
Cell Death Dis. 2020 Nov 16;11(11):983. doi: 10.1038/s41419-020-03195-1.
FAM134B (also called JK-1, RETREG1), a member of the family with sequence similarity 134, was originally discovered as an oncogene in esophageal squamous cell carcinoma. However, its most famous function is that of an ER-phagy-regulating receptor. Over the decades, the powerful biological functions of FAM134B were gradually revealed. Overwhelming evidence indicates that its dysfunction is related to pathophysiological processes such as neuropathy, viral replication, inflammation, and cancer. This review describes the biological functions of FAM134B, focusing on its role in ER-phagy. In addition, we summarize the diseases in which it is involved and review the underlying mechanisms.
FAM134B（也称为 JK-1、RETREG1），是家族性序列相似性 134 成员，最初在食管鳞状细胞癌中被发现是一种癌基因。然而，它最著名的功能是作为内质网自噬调节受体。几十年来，FAM134B 的强大生物学功能逐渐被揭示。大量证据表明，其功能障碍与神经病、病毒复制、炎症和癌症等病理生理过程有关。本综述描述了 FAM134B 的生物学功能，重点介绍其在内质网自噬中的作用。此外，我们总结了其涉及的疾病，并综述了潜在的机制。
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