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用于治疗难治性良性结直肠吻合口狭窄的 uncovered 自扩张金属支架。

Uncovered self-expandable metal stents for the treatment of refractory benign colorectal anastomotic stricture.

机构信息

Department of Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea.

Division of Gastroenterology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

出版信息

Sci Rep. 2020 Nov 16;10(1):19841. doi: 10.1038/s41598-020-76779-8.

Abstract

Self-expandable metal stent (SEMS) placement has been suggested as a therapeutic modality for treating benign colorectal strictures. Covered stents are generally used, given the concerns regarding the efficacy and safety of uncovered stents. Hence, few studies have evaluated the efficacy and safety of uncovered SEMSs (UCSEMSs) in patients with refractory benign colorectal anastomotic strictures. In this study, 12 patients with postoperative benign symptomatic anastomotic strictures refractory to pneumatic dilation (range, 2-9) and transient indwelling-covered SEMSs were treated using UCSEMS. All enrolled patients were men (mean age, 61 years). Stent placement was successful in all 12 patients, and early clinical success was achieved in 11 (92%) patients. Four patients (25%) showed successful clinical outcomes without further intervention, but eight patients (75%) were clinically unsuccessful, and showed stricture recurrence or functional obstructive symptoms. Three patients underwent surgery, and the remaining five patients required repeat stent procedures. Despite the high reobstruction rate, the median follow-up period after UCSEMS placement was 16.7 months, demonstrating that UCSEMS may be able to achieve medium-term symptom relief without any complications. Therefore, UCSEMS may be an alternative option in exceptional circumstances in carefully selected patients, where invasive surgical treatments, such as stoma diversion, are not an option, thereby improving patients' quality of life.

摘要

自膨式金属支架(SEMS)已被建议作为治疗良性结直肠狭窄的一种治疗方法。由于对无覆盖支架的疗效和安全性存在担忧,通常使用覆盖支架。因此,很少有研究评估不可覆盖的 SEMS(UCSEMS)在难治性良性结直肠吻合口狭窄患者中的疗效和安全性。在这项研究中,12 例术后良性症状性吻合口狭窄患者,对气动扩张(范围 2-9)和暂时性留置覆盖 SEMS 治疗无效,采用 UCSEMS 治疗。所有入组患者均为男性(平均年龄 61 岁)。12 例患者支架置入均成功,11 例(92%)患者早期临床效果良好。4 例(25%)患者无进一步干预即获得成功的临床结果,但 8 例(75%)患者临床效果不佳,出现狭窄复发或功能性梗阻症状。3 例患者接受了手术,其余 5 例患者需要再次进行支架治疗。尽管再梗阻率较高,但 UCSEMS 放置后中位随访时间为 16.7 个月,表明 UCSEMS 可能能够在无任何并发症的情况下实现中期症状缓解。因此,在某些特殊情况下,如肠造口术等有创治疗不可行时,UCSEMS 可能是一种替代选择,从而提高患者的生活质量。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1455/7669833/9ec43f80b305/41598_2020_76779_Fig1_HTML.jpg

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