Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario, Canada.
Nat Chem Biol. 2020 Dec;16(12):1331-1342. doi: 10.1038/s41589-020-00693-3. Epub 2020 Nov 16.
Ion channels play critical roles in cellular function by facilitating the flow of ions across the membrane in response to chemical or mechanical stimuli. Ion channels operate in a lipid bilayer, which can modulate or define their function. Recent technical advancements have led to the solution of numerous ion channel structures solubilized in detergent and/or reconstituted into lipid bilayers, thus providing unprecedented insight into the mechanisms underlying ion channel-lipid interactions. Here, we describe how ion channel structures have evolved to respond to both lipid modulators and lipid activators to control the electrical activities of cells, highlighting diverse mechanisms and common themes.
离子通道在细胞功能中起着至关重要的作用，通过响应化学或机械刺激促进离子在膜中的流动。离子通道在脂质双层中运行，脂质双层可以调节或定义其功能。最近的技术进步导致了许多以去污剂溶解或以脂质双层重新构建的离子通道结构的解决，从而为离子通道-脂质相互作用的机制提供了前所未有的见解。在这里，我们描述了离子通道结构如何进化以响应脂质调节剂和脂质激活剂来控制细胞的电活动，突出了不同的机制和共同的主题。
