Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
Biochim Biophys Acta Biomembr. 2020 Sep 1;1862(9):183304. doi: 10.1016/j.bbamem.2020.183304. Epub 2020 Apr 18.
Pentameric ligand-gated ion channels (pLGICs) play a central role in synaptic communication and are implicated in a plethora of neurological disorders leading to human disease. Membrane lipids are known to modulate pLGIC function, but the mechanisms underlying their effects are poorly understood. Recent structures reveal sites for the binding of membrane lipids to pLGICs, thus providing a structural basis for interpreting functional data on pLGIC-lipid interactions. Here, we review the literature describing the known functional effects of membrane lipids on different members of the pLGIC superfamily and highlight pLGIC structures that exhibit bound lipids. We discuss new insight into the mechanisms of pLGIC-lipid interactions that has been derived from these recent structures.
五聚体配体门控离子通道（pLGICs）在突触通讯中发挥核心作用，并与导致人类疾病的多种神经紊乱相关。已知膜脂可调节 pLGIC 的功能，但对其作用机制知之甚少。最近的结构揭示了 pLGIC 与膜脂结合的位点，从而为解释 pLGIC-脂质相互作用的功能数据提供了结构基础。本文综述了描述不同 pLGIC 超家族成员的膜脂对其功能影响的文献，并重点介绍了具有结合脂类的 pLGIC 结构。我们讨论了从这些最近的结构中得出的关于 pLGIC-脂质相互作用机制的新见解。
