Oyewande Azeezat A, Iqbal Beenish, Abdalla Lamis F, Karim Fazida, Khan Safeera
Family Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
Family Medicine, Lagos State Health Service Commission/Alimosho General Hospital, Lagos, NGA.
Cureus. 2020 Oct 14;12(10):e10947. doi: 10.7759/cureus.10947.
Obesity and diabetes both mediate their effects through insulin resistance and frequently co-exist. Insulin resistance is one of the key factors in the development of the metabolic syndrome. Adult females tend to develop obesity more frequently than males. One of the factors causing this difference is the pattern of changes that occur as females age from pre-menopausal to the post-menopausal stage, causing a change in the pattern of accumulation of fats. Several studies have explored and described the association between obesity and metabolic syndrome and their effect on type II diabetes. We conducted our literature search using PubMed and Google Scholar as our primary databases. We selected a total of 49 articles for review after applying the inclusion and exclusion criteria and removing the duplicate articles. We chose the full-text articles that were published in the English language only. The selected studies were randomized controlled trials and review papers. The reviewed articles showed that visceral fat, central obesity, and fasting blood sugar of post-menopausal is higher than in pre-menopausal women and needs adequate management. More studies are needed in the future to explore the patterns of the metabolic changes in obese females to provide early and better management of diabetes and prevent related complications.
肥胖和糖尿病都通过胰岛素抵抗介导其作用，且常常同时存在。胰岛素抵抗是代谢综合征发展的关键因素之一。成年女性比男性更容易发生肥胖。造成这种差异的因素之一是女性从绝经前到绝经后阶段随年龄增长所发生的变化模式，这导致了脂肪堆积模式的改变。几项研究已经探讨并描述了肥胖与代谢综合征之间的关联及其对2型糖尿病的影响。我们以PubMed和谷歌学术搜索作为主要数据库进行文献检索。在应用纳入和排除标准并去除重复文章后，我们共选择了49篇文章进行综述。我们只选择了以英文发表的全文文章。所选研究为随机对照试验和综述论文。综述文章表明，绝经后女性的内脏脂肪、中心性肥胖和空腹血糖高于绝经前女性，需要进行适当管理。未来需要更多研究来探索肥胖女性的代谢变化模式，以便为糖尿病提供早期和更好的管理并预防相关并发症。
