Division of Endocrinology and Metabolism, Department of Internal Medicine, Myongji Hospital, Hanyang University College of Medicine, Gyeonggi-do, Republic of Korea.
Department of Medical Statistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Sci Rep. 2020 Feb 11;10(1):2313. doi: 10.1038/s41598-020-59203-z.
We investigated the relationship of changes in Metabolic syndrome (MetS) and its components with the risk of type 2 diabetes (T2D) in South Korea. Records of 10,806,716 adults aged ≥ 20 years without a history of T2D between 2009 and 2015 were retrieved from database of the South Korean National Health Insurance Service and analyzed. Changes in metabolic components were monitored over a two-year period with follow-up occurring at an average of 4.087 years. During the follow-up period, 848,859 individuals were diagnosed with T2D. The risk of diabetes was lowered with a decrease in the number of MetS components at baseline and the second visit (p for trend <0.0001). Multivariable-adjusted HRs for incident diabetes were 0.645 among individuals with reduced number of MetS components, 0.54 for those with improvement in elevated fasting glucose, 0.735 for those with improvement in elevated triglycerides, 0.746 for those with improvement in elevated blood pressure, 0.763 for those with improvement in reduced HDL-cholesterol, and 0.92 for those with improvement in abdominal obesity compared with those manifesting them at both time points. In conclusion, changes in metabolic syndrome and its components were significantly associated with the development of T2D. Improvement in MetS and its components attenuated the risk of diabetes.
我们研究了代谢综合征（MetS）及其组成部分的变化与韩国 2 型糖尿病（T2D）风险之间的关系。从韩国国家健康保险服务数据库中检索了 2009 年至 2015 年间无 T2D 病史的 10,806,716 名年龄≥20 岁成年人的记录，并进行了分析。在两年的时间里监测了代谢成分的变化，随访平均时间为 4.087 年。在随访期间，848,859 人被诊断患有 T2D。基线和第二次就诊时 MetS 成分数量减少与糖尿病风险降低相关（趋势检验 p<0.0001）。多变量调整后的 HR 为：MetS 成分减少的个体发生糖尿病的 HR 为 0.645；空腹血糖升高改善的个体为 0.54；甘油三酯升高改善的个体为 0.735；血压升高改善的个体为 0.746；高密度脂蛋白胆固醇降低改善的个体为 0.763；腹型肥胖改善的个体为 0.92。与两个时间点都表现出代谢综合征的个体相比。综上所述，代谢综合征及其组成部分的变化与 T2D 的发生显著相关。代谢综合征及其组成部分的改善降低了糖尿病的风险。
