Department of Mother and Child Health Research, 172472Institute for Clinical Effectiveness and Health Policy (IECS-CONICET), Buenos Aires, Argentina.
Department of Human Biology, Faculty of Health Sciences, 37716University of Cape Town, South Africa.
Food Nutr Bull. 2020 Sep;41(3):332-342. doi: 10.1177/0379572120944671.
Obesity is a major and challenging public health problem. The aim of this substudy is to evaluate the effect of calcium supplementation on body weight in women recruited in the Calcium and Preeclampsia trial.
Women were recruited before pregnancy and randomized to receive a calcium supplement containing 500 mg of elemental calcium or placebo until 20 weeks' gestation; all women received 1.5 g from 20 weeks until delivery.
A total of 630 women conceived during the study, 322 allocated to calcium and 308 to placebo. Among these, 230 allocated to calcium and 227 allocated to placebo had information on body weight at baseline and at 8 weeks' gestation. During the study period, women allocated to calcium had a mean weight increase of 1.1 (SD ±5.5) kg, whereas those allocated to placebo had a mean increase of 1.5 (SD ±6.1) kg, a mean difference of 0.4 kg (95% -0.4 (-1.4 to 0.6); = .408). Women classified as obese at the start of the trial had a lower body weight gain at 8 weeks' gestation (1.0 kg; 95% CI: -3.2 to 1.2; = .330) and at 32 weeks' gestation (2.1 kg; 95% CI: 5.6-1.3; = .225) if they received calcium as compared to placebo. However, none of these differences were statistically significant.
The smaller increase in body weight found in women supplemented with 500 mg elemental calcium daily is quantitatively consistent with previous studies. However, in this study, the difference was not statistically significant.
肥胖是一个主要且具有挑战性的公共卫生问题。本亚研究旨在评估钙补充剂对钙和子痫前期试验中招募的女性体重的影响。
在妊娠前招募女性，并随机分配至接受含有 500 毫克元素钙的钙补充剂或安慰剂，直至 20 周妊娠；所有女性从 20 周开始至分娩时均接受 1.5 克。
在研究期间，共有 630 名女性怀孕，322 名分配至钙组，308 名分配至安慰剂组。其中，230 名分配至钙组和 227 名分配至安慰剂组有基线和 8 周妊娠时的体重信息。在研究期间，分配至钙组的女性体重平均增加 1.1（SD ±5.5）kg，而分配至安慰剂组的女性体重平均增加 1.5（SD ±6.1）kg，平均差异为 0.4 kg（95%置信区间：-0.4（-1.4 至 0.6）； =.408）。在试验开始时被归类为肥胖的女性在 8 周妊娠时体重增加较低（1.0kg；95%置信区间：-3.2 至 1.2； =.330），在 32 周妊娠时体重增加较低（2.1kg；95%置信区间：5.6-1.3； =.225）如果与安慰剂相比接受钙补充。然而，这些差异均无统计学意义。
每天补充 500 毫克元素钙的女性体重增加较小，与之前的研究在数量上一致。然而，在本研究中，差异无统计学意义。
