CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Biomedical Genomics and Oncogenetics Research Laboratory, Faculty of Sciences and Techniques of Tangier, University Abdelmalek Essaâdi, Tetouan, Morocco.
Endocr Metab Immune Disord Drug Targets. 2021;21(10):1760-1774. doi: 10.2174/1871530320999201116200940.
Within the pathophysiology of epilepsy, as a chronic brain disorder, the involvement of neuroinflammation has been extensively implied. Recurrent seizures of epilepsy have been associated with elevated levels of immune mediators that seem to play a pivotal role in triggering them. Neurons, glia, and endothelial cells of the blood-brain barrier (BBB) take part in such inflammatory processes by expressing receptors of associated mediators through autocrine and paracrine stimulation of intracellular signaling pathways. In this milieu, elevated cytokine levels in serum and brain tissue have been reported in patients with an epileptic profile. Noteworthy, interleukin (IL)-1β, IL-6, and tumor necrosis factor-alpha (TNF-α) are the proinflammatory cytokines mostly associated, in literature, with the pathogenesis of epilepsies. In this review, we examine the function of these cytokines in connection with transforming growth factor-beta (TGF-β), IL-8, IL-12, IL-18, and macrophage inflammatory protein (MIP) as potential proinflammatory mediators in the neuropathology of epilepsy.
在癫痫的病理生理学中，作为一种慢性脑部疾病，神经炎症的参与已被广泛暗示。癫痫的反复发作与免疫介质水平升高有关，这些免疫介质似乎在引发癫痫发作中起着关键作用。神经元、神经胶质细胞和血脑屏障（BBB）的内皮细胞通过通过自分泌和旁分泌刺激细胞内信号通路来表达相关介质的受体，从而参与这种炎症过程。在这种环境中，有癫痫特征的患者的血清和脑组织中的细胞因子水平升高。值得注意的是，白细胞介素（IL）-1β、IL-6 和肿瘤坏死因子-α（TNF-α）是与癫痫发病机制最相关的促炎细胞因子。在这篇综述中，我们研究了这些细胞因子与转化生长因子-β（TGF-β）、IL-8、IL-12、IL-18 和巨噬细胞炎症蛋白（MIP）的功能联系，这些细胞因子作为癫痫神经病理学中的潜在促炎介质。
