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TRIB1 silencing attenuates epilepsy by restoring mitochondrial homeostasis and suppressing microglia-driven neuroinflammation via MAPK pathway inhibition.

作者信息

Liao Chunying, Cao Jie, Zeng Hanyi, Chen Cuiyin, Yuan Jianqing

机构信息

Department of Neurology, The First Affiliated Hospital of Gannan Medical University, No.128, Jinling Road, Zhanggong District, Ganzhou, 341000, Jiangxi, China.

出版信息

J Mol Histol. 2025 Sep 5;56(5):295. doi: 10.1007/s10735-025-10580-7.

DOI:10.1007/s10735-025-10580-7
PMID:40908404
Abstract
摘要

相似文献

1
TRIB1 silencing attenuates epilepsy by restoring mitochondrial homeostasis and suppressing microglia-driven neuroinflammation via MAPK pathway inhibition.TRIB1基因沉默通过恢复线粒体稳态和抑制丝裂原活化蛋白激酶（MAPK）信号通路介导的小胶质细胞驱动的神经炎症来减轻癫痫。
J Mol Histol. 2025 Sep 5;56(5):295. doi: 10.1007/s10735-025-10580-7.
2
ERK1/2 regulates hepatocyte Trib1 in response to mitochondrial dysfunction.细胞外信号调节激酶1/2（ERK1/2）在应对线粒体功能障碍时调节肝细胞中的TRIB1。
Biochim Biophys Acta. 2013 Dec;1833(12):3405-3414. doi: 10.1016/j.bbamcr.2013.10.001. Epub 2013 Oct 24.
3
Silencing ATF3 mediates mitochondrial homeostasis and improves ischemic stroke through regulating the MAPK signaling pathway.沉默激活转录因子3通过调节丝裂原活化蛋白激酶信号通路介导线粒体稳态并改善缺血性中风。
Front Mol Neurosci. 2025 Jun 20;18:1554802. doi: 10.3389/fnmol.2025.1554802. eCollection 2025.
4
Macrophage migration is controlled by Tribbles 1 through the interaction between C/EBPβ and TNF-α.巨噬细胞迁移由Tribbles 1通过C/EBPβ与TNF-α之间的相互作用来控制。
Vet Immunol Immunopathol. 2013 Sep 1;155(1-2):67-75. doi: 10.1016/j.vetimm.2013.06.001. Epub 2013 Jun 6.
5
Regulation of TRIB1 abundance in hepatocyte models in response to proteasome inhibition.TRIB1 丰度在肝细胞模型中对蛋白酶体抑制的响应的调节。
Sci Rep. 2023 Jun 8;13(1):9320. doi: 10.1038/s41598-023-36512-7.
6
hUMSC-Exosomes suppress TREM1-p38 MAPK signaling via HMGB1-dependent mechanisms to reprogram microglial function and promote neuroprotection in ischemic stroke.人脐带间充质干细胞外泌体通过HMGB1依赖性机制抑制TREM1-p38丝裂原活化蛋白激酶信号传导，从而重塑小胶质细胞功能并促进缺血性中风的神经保护作用。
J Nanobiotechnology. 2025 Aug 19;23(1):572. doi: 10.1186/s12951-025-03652-z.
7
The Pseudokinase TRIB1 in Immune Cells and Associated Disorders.免疫细胞中的假激酶TRIB1及其相关疾病
Cancers (Basel). 2022 Feb 17;14(4):1011. doi: 10.3390/cancers14041011.
8
Tribbles in disease: Signaling pathways important for cellular function and neoplastic transformation.疾病中的 Tribbles：对细胞功能和肿瘤转化重要的信号通路。
Cancer Sci. 2011 Jun;102(6):1115-22. doi: 10.1111/j.1349-7006.2011.01914.x. Epub 2011 Mar 18.
9
The role of Trib1 in myeloid leukaemogenesis and differentiation.TRIB1在髓系白血病发生和分化中的作用。
Biochem Soc Trans. 2015 Oct;43(5):1104-7. doi: 10.1042/BST20150110.
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Tribbles homolog 1 deficiency modulates function and polarization of murine bone marrow-derived macrophages.Tribbles 同源物 1 缺乏可调节小鼠骨髓来源巨噬细胞的功能和极化。
J Biol Chem. 2018 Jul 20;293(29):11527-11536. doi: 10.1074/jbc.RA117.000703. Epub 2018 Jun 13.

本文引用的文献

1
Structural remodeling of the brain cortex and functional recovery following hypoglossal-facial neurorrhaphy in patients with facial paralysis.面瘫患者舌下-面神经吻合术后大脑皮质的结构重塑与功能恢复
Brain Res. 2025 Feb 15;1849:149437. doi: 10.1016/j.brainres.2024.149437. Epub 2024 Dec 28.
2
UCP2, a Member of the Mitochondrial Uncoupling Proteins: An Overview from Physiological to Pathological Roles.UCP2，线粒体解偶联蛋白家族成员：从生理作用到病理作用的概述
Biomedicines. 2024 Jun 13;12(6):1307. doi: 10.3390/biomedicines12061307.
3
WONOEP 2022: Neurotechnology for the diagnosis of epilepsy.
WONOEP 2022：癫痫的神经技术诊断。
Epilepsia. 2024 Aug;65(8):2238-2247. doi: 10.1111/epi.18028. Epub 2024 Jun 3.
4
Focusing on mitochondria in the brain: from biology to therapeutics.关注大脑中的线粒体：从生物学到治疗学。
Transl Neurodegener. 2024 Apr 17;13(1):23. doi: 10.1186/s40035-024-00409-w.
5
A Comprehensive Metabolism-Related Gene Signature Predicts the Survival of Patients with Acute Myeloid Leukemia.一个全面的代谢相关基因特征可预测急性髓系白血病患者的生存情况。
Genes (Basel). 2023 Dec 31;15(1):63. doi: 10.3390/genes15010063.
6
LTN1 promotes RLR degradation to inhibit immune response to RNA virus through the ESCRT pathway.LTN1 通过 ESCRT 途径促进 RLR 降解，从而抑制对 RNA 病毒的免疫反应。
Autophagy. 2024 Jun;20(6):1270-1285. doi: 10.1080/15548627.2023.2291939. Epub 2023 Dec 13.
7
Genetic Background of Epilepsy and Antiepileptic Treatments.癫痫的遗传背景和抗癫痫治疗。
Int J Mol Sci. 2023 Nov 14;24(22):16280. doi: 10.3390/ijms242216280.
8
Epilepsy: Mitochondrial connections to the 'Sacred' disease.癫痫：与“神圣”疾病的线粒体联系。
Mitochondrion. 2023 Sep;72:84-101. doi: 10.1016/j.mito.2023.08.002. Epub 2023 Aug 13.
9
Astrocyte-derived SerpinA3N promotes neuroinflammation and epileptic seizures by activating the NF-κB signaling pathway in mice with temporal lobe epilepsy.星形胶质细胞衍生的丝氨酸蛋白酶抑制剂 A3N 通过激活小胶质细胞 NF-κB 信号通路促进颞叶癫痫小鼠神经炎症和癫痫发作。
J Neuroinflammation. 2023 Jul 8;20(1):161. doi: 10.1186/s12974-023-02840-8.
10
TRIB1 regulates liver regeneration by antagonizing the NRF2-mediated antioxidant response.TRIB1 通过拮抗 NRF2 介导的抗氧化反应来调节肝脏再生。
Cell Death Dis. 2023 Jun 24;14(6):372. doi: 10.1038/s41419-023-05896-9.