急性扁桃体咽炎患儿感染细菌药敏评估。

Antibiotic Susceptibility Evaluation of Bacterial Agents Causing Infection in Children with Acute Tonsillopharyngitis.

机构信息

Department of Pediatrics, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

Internal Medicine Department, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.

出版信息

Infect Disord Drug Targets. 2021;21(6):e170721187997. doi: 10.2174/1871526520666201116102441.

DOI:10.2174/1871526520666201116102441

PMID:33200718

Abstract

BACKGROUND

The aim of this study is to evaluate the prevalence of group A beta-hemolytic pharyngitis by assessing the outcome of the culture and the resistance and sensitivity of group A beta hemolytic Streptococcus to antibiotics.

METHODS

This cross-sectional study was conducted on 170 patients aged 3-15 years, referred to the clinic with complaints of sore throat. Patients' history was collected and physical examination was performed and was score based on clinical findings. Patients with other underlying pathologies and those taking antibiotics prior to the study were excluded from our study. Antimicrobial susceptibility test was performed by disk diffusion method against cephalexin, cefazolin, erythromycin and amoxicillin.

RESULTS

A total of 170 patients were reported with sore throat. Patients with positive culture results were 60% male and 40% female. Amoxicillin resistance was the greatest (5%) in the culture. All isolated bacteria were sensitive to amoxicillin, cephalexin, cefazolin and erythromycin. Patients with McIssac score ≥ 6 showed clinical sensitivity 75% specificity 61% negative predictive value 94.8% and positive predictive value 20.3% for Group A beta-hemolytic streptococcal pharyngitis.

CONCLUSION

The results showed the higher the clinical score, the greater the chance of positive throat culture.

摘要

背景

本研究旨在通过评估培养物的结果以及 A 组β溶血性链球菌对抗生素的耐药性和敏感性，来评估 A 组β溶血性咽峡炎的患病率。

方法

这是一项横断面研究，共纳入了 170 名 3-15 岁的患者，他们因咽痛就诊。采集患者的病史并进行体格检查，根据临床发现进行评分。患有其他潜在疾病和在研究前使用抗生素的患者被排除在本研究之外。采用纸片扩散法对头孢氨苄、头孢唑林、红霉素和阿莫西林进行抗菌药物敏感性试验。

结果

共报告了 170 例咽痛患者。阳性培养结果的患者中，男性占 60%，女性占 40%。在培养物中，阿莫西林的耐药率最高（5%）。所有分离出的细菌对阿莫西林、头孢氨苄、头孢唑林和红霉素均敏感。McIssac 评分≥6 的患者中，A 组β溶血性链球菌性咽峡炎的临床敏感性为 75%，特异性为 61%，阴性预测值为 94.8%，阳性预测值为 20.3%。