Tadesse Molla, Hailu Yohanes, Biset Sirak, Ferede Getachew, Gelaw Baye
Department of Medical Microbiology, Jigjiga University, Jigjiga, Ethiopia.
Department of Pediatrics and Child Health, School of Medicine, University of Gondar, Gondar, Ethiopia.
Infect Drug Resist. 2023 Mar 22;16:1637-1648. doi: 10.2147/IDR.S402292. eCollection 2023.
() or group A is a common cause of bacterial pharyngitis in children. Since it is difficult to distinguish between viral and bacterial pharyngitis using solely signs and symptoms, culture-based diagnosis and treatment are critical for avoiding serious complications. Therefore, this study aimed to determine the prevalence, antimicrobial susceptibility patterns, and associated factors of among pediatric patients with acute pharyngitis.
A hospital-based cross-sectional study was conducted at the University of Gondar Comprehensive Specialized Hospital from April to June 2021. Standard microbiological procedures were used to collect and process throat swabs and to isolate and identify . The disc diffusion method was used for antimicrobial susceptibility testing (AST).
A total of 215 children with acute pharyngitis were included in this study. Of these, 23 (10.7%) were culture positive for . The presence of an inflamed tonsil, tonsillar exudate, scalariform rash, and dysphagia were associated with streptococcal pharyngitis. Children aged 5 to 15 were more susceptible to streptococcal throat infection than younger children. Penicillin, vancomycin, chloramphenicol, clindamycin, and ceftriaxone were effective against 100%, 95.7%, 95.7%, 91%, and 87% of isolates, respectively. In contrast, 56.5%, 39.1%, and 30.4% of isolates showed at least reduced susceptibility to tetracycline, erythromycin, and azithromycin, respectively.
is responsible for 10.7% of acute pharyngitis cases among pediatric patients in the study area. Although all isolates remain sensitive to penicillin, many showed reduced susceptibility to tetracycline and macrolides. Therefore, prior to antibiotic prescription, screening children with acute pharyngitis for and testing the antibiotic susceptibility of isolates is recommended.
（）或A组是儿童细菌性咽炎的常见病因。由于仅通过体征和症状难以区分病毒性咽炎和细菌性咽炎，基于培养的诊断和治疗对于避免严重并发症至关重要。因此，本研究旨在确定急性咽炎儿科患者中（）的患病率、抗菌药物敏感性模式及相关因素。
2021年4月至6月在贡德尔大学综合专科医院进行了一项基于医院的横断面研究。采用标准微生物学程序收集和处理咽拭子，分离和鉴定（）。采用纸片扩散法进行抗菌药物敏感性试验（AST）。
本研究共纳入215例急性咽炎儿童。其中，23例（10.7%）（）培养阳性。扁桃体发炎、扁桃体渗出物、线状皮疹和吞咽困难与链球菌性咽炎相关。5至15岁的儿童比年幼儿童更容易发生链球菌性咽喉感染。青霉素、万古霉素、氯霉素、克林霉素和头孢曲松分别对100%、95.7%、95.7%、91%和87%的分离株有效。相比之下，分别有56.5%、39.1%和30.4%的分离株对四环素、红霉素和阿奇霉素至少表现出敏感性降低。
在研究区域的儿科患者中，（）导致了10.7%的急性咽炎病例。尽管所有分离株对青霉素仍敏感，但许多分离株对四环素和大环内酯类药物表现出敏感性降低。因此，在开具抗生素之前，建议对急性咽炎儿童进行（）筛查并检测分离株的抗生素敏感性。
