碳酸锂治疗卡马西平诱导的抗利尿激素不适当分泌综合征
Lithium for Carbamazepine-Induced Syndrome of Inappropriate Antidiuretic Hormone.
机构信息
University of South Florida Health Morsani College of Medicine, Department of Psychiatry and Behavioral Neurosciences, Tampa, FL.
James A Haley VA Hospital, Mental Health and Behavioral Sciences Service, Tampa, FL.
出版信息
Clin Neuropharmacol. 2021;44(1):33-34. doi: 10.1097/WNF.0000000000000421.
OBJECTIVES
To examine the effectiveness of low-dose lithium carbonate for managing carbamazepine-induced hyponatremia.
METHODS
Single case study in an 88 year old man with bipolar illness and vascular dementia who had failed to respond to other mood stabilizers.
RESULTS
The patient had developed hyponatremia on two separate occasions when treated with carbamazepine. Introduction of low-dose lithium resulted in prompt normalization of serum sodium levels, which was maintained for the subsequent 8 weeks.
CONCLUSIONS
Carbamazepine may sometimes be the best or only viable treatment option for patients with bipolar illness or other conditions. When its use is complicated by syndrome of inappropriate ADH, dose reduction and fluid restriction are the simplest options but, if ineffective, addition of lithium may be a feasible, albeit somewhat complicated, alternative.
目的
探讨小剂量碳酸锂治疗卡马西平引起的低钠血症的疗效。
方法
对 1 例 88 岁的双相情感障碍和血管性痴呆患者进行单病例研究，该患者对其他心境稳定剂治疗反应不佳。
结果
该患者在使用卡马西平的两次不同情况下均出现低钠血症。使用小剂量锂后，血清钠水平迅速恢复正常，并在随后的 8 周内保持稳定。
结论
卡马西平有时可能是治疗双相情感障碍或其他疾病患者的最佳或唯一可行的治疗选择。当它的使用因抗利尿激素不适当分泌综合征而变得复杂时，减少剂量和限制液体摄入是最简单的选择，但如果无效，添加锂可能是一种可行的选择，尽管有点复杂。
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