Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiabá, MT, 78 043 306, Brazil.
Tropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil.
Arch Gynecol Obstet. 2021 Mar;303(3):739-749. doi: 10.1007/s00404-020-05867-x. Epub 2020 Nov 17.
Knowledge of adolescent and adult phenotypes of women with polycystic ovary syndrome (PCOS) might drive opportune management. The aim of this study was to compare metabolic and obesity biomarkers between adolescent and adult women with PCOS.
This observational study compared biomarkers of obesity and metabolism derangements between adolescent (n = 62) and adult (n = 248) women with PCOS. Predictors of metabolic syndrome (MS) were investigated using univariate and multivariate binary logistic regression analysis.
The postmenarcheal age of adolescents was 4.9 ± 0.03 years. Systolic blood pressure was lower in adolescents than in adults (112.3 mmHg vs 117.0 mmHg, p = 0.001) Diastolic blood pressure was also lower in adolescents (70.7 mmHg vs 75.8 mmHg, p < 0.001). Glucose intolerance (12.0% vs 19.3%) and insulin resistance (18.2% vs 17.7%) were similar in both groups (p > 0.05, for comparisons). Impaired fasting glucose was lower in adolescents (1.8% vs 11.6%, p = 0.015). Total cholesterol and low-density lipoprotein cholesterol were lower in adolescents (p < 0.001). MS in adolescents and adults were found in 10.3% and 27.8%, respectively (p = 0.005). Visceral adiposity index (VAI) was a good predictor of MS in both adolescents (OR = 12.2), and adults (OR = 9.7).
Most biomarkers of glucose metabolism abnormalities were similar in adolescents and adults with PCOS. The prevalence of MS was lower in adolescents. VAI was a strong predictor of metabolic syndrome, both in adolescent and adult women with PCOS.
了解多囊卵巢综合征（PCOS）女性的青少年和成年表型可能有助于及时治疗。本研究旨在比较青少年和成年 PCOS 女性的代谢和肥胖生物标志物。
本观察性研究比较了 62 名青少年和 248 名成年 PCOS 女性的肥胖和代谢紊乱生物标志物。使用单变量和多变量二元逻辑回归分析研究了代谢综合征（MS）的预测因素。
青少年的初潮年龄为 4.9±0.03 岁。青少年的收缩压低于成年人（112.3mmHg 比 117.0mmHg，p=0.001），舒张压也较低（70.7mmHg 比 75.8mmHg，p<0.001）。两组葡萄糖耐量异常（12.0%比 19.3%）和胰岛素抵抗（18.2%比 17.7%）相似（p>0.05）。青少年空腹血糖受损发生率较低（1.8%比 11.6%，p=0.015）。青少年的总胆固醇和低密度脂蛋白胆固醇水平较低（p<0.001）。青少年和成年患者的 MS 发生率分别为 10.3%和 27.8%（p=0.005）。在青少年（OR=12.2）和成年（OR=9.7）患者中，内脏脂肪指数（VAI）是 MS 的良好预测因子。
青少年和成年 PCOS 患者的葡萄糖代谢异常生物标志物大多相似。青少年的 MS 患病率较低。VAI 是青少年和成年 PCOS 患者代谢综合征的强有力预测因子。
