Department of Gynecology and Obstetrics, Medical School, Federal University of Mato Grosso, Cuiabá, MT, Brazil.
Tropical Institute of Reproductive Medicine, Cuiabá, MT, Brazil.
Rev Endocr Metab Disord. 2022 Apr;23(2):251-264. doi: 10.1007/s11154-022-09715-y. Epub 2022 Feb 26.
This comprehensive review aimed to evaluate the relationship between SARS-CoV-2 infection (the cause of coronavirus disease 2019, or COVID-19) and the metabolic and endocrine characteristics frequently found in women with polycystic ovary syndrome (PCOS). In the general population, COVID-19 is more severe in subjects with dyslipidemia, obesity, diabetes mellitus, and arterial hypertension. Because these conditions are comorbidities commonly associated with PCOS, it was hypothesized that women with PCOS would be at higher risk for acquiring COVID-19 and developing more severe clinical presentations. This hypothesis was confirmed in several epidemiological studies. The present review shows that women with PCOS are at 28%-50% higher risk of being infected with the SARS-CoV-2 virus at all ages and that, in these women, COVID-19 is associated with increased rates of hospitalization, morbidity, and mortality. We summarize the mechanisms of the higher risk of COVID-19 infection in women with PCOS, particularly in those with carbohydrate and lipid abnormal metabolism, hyperandrogenism, and central obesity.
本综述旨在评估 SARS-CoV-2 感染（导致 2019 年冠状病毒病，即 COVID-19）与多囊卵巢综合征（PCOS）妇女中常见的代谢和内分泌特征之间的关系。在一般人群中，血脂异常、肥胖、糖尿病和动脉高血压的 COVID-19 患者病情更为严重。由于这些疾病是 PCOS 的常见合并症，因此有人假设 PCOS 妇女感染 COVID-19 的风险更高，出现更严重的临床症状。这一假设在几项流行病学研究中得到了证实。本综述表明，各年龄段 PCOS 妇女感染 SARS-CoV-2 病毒的风险增加 28%-50%，而且 COVID-19 与住院率、发病率和死亡率升高相关。我们总结了 PCOS 妇女感染 COVID-19 风险较高的机制，尤其是在那些存在碳水化合物和脂质代谢异常、高雄激素血症和中心性肥胖的妇女中。
