• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

混合谱系白血病 1 有助于子宫内膜基质细胞在蜕膜化过程中对孕激素的反应性。

Mixed-lineage leukaemia 1 contributes to endometrial stromal cells progesterone responsiveness during decidualization.

机构信息

Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, China.

Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, China.

出版信息

J Cell Mol Med. 2021 Jan;25(1):297-308. doi: 10.1111/jcmm.16030. Epub 2020 Nov 17.

DOI:10.1111/jcmm.16030
PMID:33201593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7810960/
Abstract

Studies have reported that non-receptive endometrium or abnormal decidualization was closely related to recurrent implantation failure (RIF). MLL1 is a histone H3 lysine 4 trimethylation (H3K4me3) transferase that regulates the transcriptional activation of target genes. The role of MLL1 has been underexplored during decidualization. In our research, we found the expression of MLL1 was closely related to endometrial receptivity, and it was responsible to hormone stimulation. Inhibiting the function of MLL1 by MM102 reduced the transformation of HESCs. Furthermore, down-regulation of MLL1 by siRNA transfection significantly decreased PGR and its target genes expression. MLL1 act as a co-activator of ERα, and both of them were recruited to PGR regulatory regions, thus promote PGR transcription. Our study showed that MLL1 plays a key role in promoting progesterone signalling transmission.

摘要

研究表明，接受性不佳的子宫内膜或异常的蜕膜化与反复着床失败（RIF）密切相关。MLL1 是一种组蛋白 H3 赖氨酸 4 三甲基化（H3K4me3）转移酶，可调节靶基因的转录激活。在蜕膜化过程中，MLL1 的作用尚未得到充分探索。在我们的研究中，我们发现 MLL1 的表达与子宫内膜的接受性密切相关，并且对激素刺激有反应。通过 MM102 抑制 MLL1 的功能会减少 HESCs 的转化。此外，通过 siRNA 转染下调 MLL1 显著降低了 PGR 及其靶基因的表达。MLL1 作为 ERα 的共激活因子发挥作用，两者都被招募到 PGR 调节区域，从而促进 PGR 转录。我们的研究表明，MLL1 在促进孕激素信号转导中发挥关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/b67edd38e3a0/JCMM-25-297-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/8871f0c701cb/JCMM-25-297-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/86e5922cae06/JCMM-25-297-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/6aac2fa5c3ad/JCMM-25-297-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/5302cec04ed0/JCMM-25-297-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/b18bed44b122/JCMM-25-297-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/a509aa123b9b/JCMM-25-297-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/b67edd38e3a0/JCMM-25-297-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/8871f0c701cb/JCMM-25-297-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/86e5922cae06/JCMM-25-297-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/6aac2fa5c3ad/JCMM-25-297-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/5302cec04ed0/JCMM-25-297-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/b18bed44b122/JCMM-25-297-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/a509aa123b9b/JCMM-25-297-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/671a/7810960/b67edd38e3a0/JCMM-25-297-g007.jpg

相似文献

1
Mixed-lineage leukaemia 1 contributes to endometrial stromal cells progesterone responsiveness during decidualization.混合谱系白血病 1 有助于子宫内膜基质细胞在蜕膜化过程中对孕激素的反应性。
J Cell Mol Med. 2021 Jan;25(1):297-308. doi: 10.1111/jcmm.16030. Epub 2020 Nov 17.
2
Decreased mixed lineage leukemia 1 is involved in endometriosis-related infertility.混合谱系白血病1表达降低与子宫内膜异位症相关的不孕症有关。
J Mol Endocrinol. 2021 Jan;66(1):45-57. doi: 10.1530/JME-20-0193.
3
Bisphenol a affects endometrial stromal cells decidualization, involvement of epigenetic regulation.双酚 A 影响子宫内膜基质细胞的蜕膜化，涉及表观遗传调控。
J Steroid Biochem Mol Biol. 2020 Jun;200:105640. doi: 10.1016/j.jsbmb.2020.105640. Epub 2020 Feb 19.
4
Growth regulation by estrogen in breast cancer 1 (GREB1) is a novel progesterone-responsive gene required for human endometrial stromal decidualization.雌激素对乳腺癌 1（GREB1）的生长调控是一种新型孕激素反应基因，是人类子宫内膜基质蜕膜化所必需的。
Mol Hum Reprod. 2017 Sep 1;23(9):646-653. doi: 10.1093/molehr/gax045.
5
G-protein coupled receptor 64 is required for decidualization of endometrial stromal cells.G 蛋白偶联受体 64 对于子宫内膜基质细胞的蜕膜化是必需的。
Sci Rep. 2017 Jul 10;7(1):5021. doi: 10.1038/s41598-017-05165-8.
6
The Promyelocytic Leukemia Zinc Finger Transcription Factor Is Critical for Human Endometrial Stromal Cell Decidualization.早幼粒细胞白血病锌指转录因子对人子宫内膜基质细胞蜕膜化至关重要。
PLoS Genet. 2016 Apr 1;12(4):e1005937. doi: 10.1371/journal.pgen.1005937. eCollection 2016 Apr.
7
EHD1 impaired decidualization of endometrial stromal cells in recurrent implantation failure: role of SENP1 in modulating progesterone receptor signalling†.EHD1损害复发性植入失败中子宫内膜基质细胞的蜕膜化：SENP1在调节孕激素受体信号传导中的作用†
Biol Reprod. 2024 Mar 13;110(3):536-547. doi: 10.1093/biolre/ioad161.
8
Reprogramming of the Epigenome by MLL1 Links Early-Life Environmental Exposures to Prostate Cancer Risk.MLL1介导的表观基因组重编程将早期环境暴露与前列腺癌风险联系起来。
Mol Endocrinol. 2016 Aug;30(8):856-71. doi: 10.1210/me.2015-1310. Epub 2016 May 24.
9
Increased Krüppel-like factor 12 in recurrent implantation failure impairs endometrial decidualization by repressing Nur77 expression.复发性植入失败中Krüppel样因子12增加通过抑制Nur77表达损害子宫内膜蜕膜化。
Reprod Biol Endocrinol. 2017 Mar 31;15(1):25. doi: 10.1186/s12958-017-0243-8.
10
Early growth response 1 transcriptionally primes the human endometrial stromal cell for decidualization.早期生长反应 1 转录激活人子宫内膜基质细胞的蜕膜化。
J Steroid Biochem Mol Biol. 2019 May;189:283-290. doi: 10.1016/j.jsbmb.2019.01.021. Epub 2019 Jan 31.

本文引用的文献

1
Bisphenol a affects endometrial stromal cells decidualization, involvement of epigenetic regulation.双酚 A 影响子宫内膜基质细胞的蜕膜化，涉及表观遗传调控。
J Steroid Biochem Mol Biol. 2020 Jun;200:105640. doi: 10.1016/j.jsbmb.2020.105640. Epub 2020 Feb 19.
2
The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions.MLL1 三聚体催化复合物是一个由多个弱相互作用稳定的动态构象集合体。
Nucleic Acids Res. 2019 Sep 26;47(17):9433-9447. doi: 10.1093/nar/gkz697.
3
Loss of HDAC3 results in nonreceptive endometrium and female infertility.
HDAC3 的缺失导致子宫内膜容受性丧失和女性不孕。
Sci Transl Med. 2019 Jan 9;11(474). doi: 10.1126/scitranslmed.aaf7533.
4
Reciprocal changes of H3K27ac and H3K27me3 at the promoter regions of the critical genes for endometrial decidualization.关键基因启动子区域 H3K27ac 和 H3K27me3 的相互变化与子宫内膜蜕膜化有关。
Epigenomics. 2018 Sep;10(9):1243-1257. doi: 10.2217/epi-2018-0006. Epub 2018 Sep 13.
5
Decreased PECAM1-mediated TGF-β1 expression in the mid-secretory endometrium in women with recurrent implantation failure.在反复着床失败的女性的中分泌期子宫内膜中，PECAM1 介导的 TGF-β1 表达降低。
Hum Reprod. 2018 May 1;33(5):832-843. doi: 10.1093/humrep/dey022.
6
Epigenetic Dynamics of HOXA10 Gene in Infertile Women With Endometriosis.子宫内膜异位症不孕妇女中 HOXA10 基因的表观遗传动态
Reprod Sci. 2019 Jan;26(1):88-96. doi: 10.1177/1933719118766255. Epub 2018 Mar 28.
7
The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia.E3 泛素连接酶 Triad1 影响 Mll-Ell 诱导的急性髓系白血病的发生。
Oncogene. 2018 May;37(19):2532-2544. doi: 10.1038/s41388-018-0131-5. Epub 2018 Feb 20.
8
IL-13 regulates human nasal epithelial cell differentiation via H3K4me3 modification.白细胞介素-13通过组蛋白H3赖氨酸4三甲基化修饰调控人鼻上皮细胞分化。
J Inflamm Res. 2017 Jan 9;10:181-188. doi: 10.2147/JIR.S149156. eCollection 2017.
9
The Histone Methyltransferase MLL1 Directs Macrophage-Mediated Inflammation in Wound Healing and Is Altered in a Murine Model of Obesity and Type 2 Diabetes.组蛋白甲基转移酶MLL1在伤口愈合中指导巨噬细胞介导的炎症反应，且在肥胖和2型糖尿病小鼠模型中发生改变。
Diabetes. 2017 Sep;66(9):2459-2471. doi: 10.2337/db17-0194. Epub 2017 Jun 29.
10
Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion.胚胎着床后蜕膜中HOXA10表达降低促进滋养层细胞侵袭。
Endocrinology. 2017 Aug 1;158(8):2618-2633. doi: 10.1210/en.2017-00032.