Terr A I, Moss R B, Strober S
Division of Immunology, Stanford University Medical Center, CA 94305.
J Allergy Clin Immunol. 1987 Dec;80(6):798-802. doi: 10.1016/s0091-6749(87)80268-3.
Thirteen patients with rheumatoid arthritis and four patients with systemic lupus erythematosus and nephritis were treated with total lymphoid irradiation because of severe disease refractory to other forms of treatment. Serum samples before and after irradiation were tested for changes in total serum IgE and for changes in specific IgE antibodies to ryegrass pollen, dust mite, cat dander, and Alternaria. There were no statistically significant changes in total or specific IgE from lymphoid irradiation in these patients. The therapy caused a significant decrease in circulating total lymphocyte and Leu-3 (helper/inducer) T-lymphocyte counts. Therefore, reduction in circulating levels of helper/inducer T cells does not appear to influence preexisting levels of IgE antibodies.
13名类风湿性关节炎患者和4名系统性红斑狼疮及肾炎患者因病情严重且对其他治疗方法无效，接受了全身淋巴照射治疗。照射前后的血清样本检测了总血清IgE的变化以及针对黑麦草花粉、尘螨、猫皮屑和链格孢的特异性IgE抗体的变化。这些患者经淋巴照射后，总IgE或特异性IgE均无统计学上的显著变化。该疗法使循环中的总淋巴细胞和Leu-3（辅助/诱导）T淋巴细胞计数显著降低。因此，辅助/诱导T细胞循环水平的降低似乎不会影响IgE抗体的原有水平。
