Tanay A, Schiffman G, Strober S
Arthritis Rheum. 1986 Jan;29(1):26-31. doi: 10.1002/art.1780290104.
The effects of total lymphoid irradiation (TLI) on serum levels of autoantibodies, and of antibodies to diphtheria toxoid, tetanus toxoid, and pneumococcal polysaccharide in patients with lupus nephritis were compared with those previously observed in rheumatoid arthritis (RA) patients. Baseline levels of antibodies to diphtheria toxoid and tetanus toxoid decreased significantly after TLI in patients with lupus and RA, but antibody levels to pneumococcal polysaccharide remained unchanged. After TLI, the levels of antinuclear and anti-DNA antibodies were reduced significantly in lupus, but levels of rheumatoid factor, antinuclear, and antigranulocyte antibodies all tended to increase in RA.
将狼疮性肾炎患者接受全身淋巴照射（TLI）后血清自身抗体水平以及抗白喉类毒素、破伤风类毒素和肺炎球菌多糖抗体水平，与先前在类风湿性关节炎（RA）患者中观察到的情况进行了比较。狼疮患者和RA患者在接受TLI后，白喉类毒素和破伤风类毒素抗体的基线水平显著下降，但肺炎球菌多糖抗体水平保持不变。接受TLI后，狼疮患者的抗核抗体和抗DNA抗体水平显著降低，但RA患者的类风湿因子、抗核抗体和抗粒细胞抗体水平均有升高趋势。
