Department of Orthopaedic Surgery, Affiliated Hospital of Zunyi Medical University, Guizhou 563000, China.
Peking University Institute of Sports Medicine, Beijing 100083, China.
Regen Med. 2020 Sep;15(9):2129-2142. doi: 10.2217/rme-2019-0080. Epub 2020 Nov 17.
Ligament/tendon and cartilage injuries are clinically common diseases that perplex most clinicians. Because of the lack of blood vessels and nerves, their self-repairing abilities are rather poor. Therefore, surgeries are necessary and also widely used to treat ligament/tendon or cartilage injuries. However, after surgery, there are still many problems that affect healing. In recent years, it has been found that exogenous FGF2 plays an important role in the repair of ligament/tendon and cartilage injuries and exerts a synergistic effect with endogenous FGF2. Therefore, FGF2 can be used as a new type of biomolecule to accelerate tendon-to-bone healing and cartilage repair after injury.
韧带/肌腱和软骨损伤是临床上常见的疾病，令大多数临床医生感到困惑。由于缺乏血管和神经，它们的自我修复能力相当差。因此，手术是必要的，也被广泛用于治疗韧带/肌腱或软骨损伤。然而，手术后仍然存在许多影响愈合的问题。近年来，人们发现外源性 FGF2 在韧带/肌腱和软骨损伤的修复中起着重要作用，并与内源性 FGF2 发挥协同作用。因此，FGF2 可以作为一种新型生物分子，加速损伤后腱骨愈合和软骨修复。
