Fehér J, Cornides A, Romány A, Kárteszi M, Szalay L, Gógl A, Picazo J
2nd Department of Medicine, Semmelweis University, Budapest, Hungary.
J Hepatol. 1987 Oct;5(2):224-31. doi: 10.1016/s0168-8278(87)80577-9.
A randomized, single-blind controlled multicenter study of insulin and glucagon infusion was carried out in 66 patients with acute alcoholic hepatitis. Thirty-three patients were treated with insulin 10 U and glucagon 1 mg in 500 ml 5% glucose in water via a peripheral vein for 2-6 h three times every day for 3 weeks. Patients in the control group received 5% glucose in an identical fashion. Fourteen control patients and five treated patients died from liver failure during the study (P less than 0.02). Clinical features of liver disease on entry into the study were similar in the two groups, but the total serum bilirubin, aspartate aminotransferase, gamma-glutamyltranspeptidase activities and prothrombin time significantly improved in the treated patients (P less than 0.05). Insulin and glucagon infusion appears to be a promising treatment of acute alcoholic hepatitis.
对66例急性酒精性肝炎患者进行了一项胰岛素和胰高血糖素输注的随机、单盲对照多中心研究。33例患者通过外周静脉每天3次给予10 U胰岛素和1 mg胰高血糖素加入500 ml 5%葡萄糖溶液中输注2 - 6小时，共治疗3周。对照组患者以相同方式接受5%葡萄糖溶液。研究期间，14例对照患者和5例治疗患者死于肝衰竭（P<0.02）。两组患者进入研究时肝病的临床特征相似，但治疗组患者的总血清胆红素、天冬氨酸转氨酶、γ-谷氨酰转肽酶活性及凝血酶原时间有显著改善（P<0.05）。胰岛素和胰高血糖素输注似乎是急性酒精性肝炎的一种有前景的治疗方法。
