Baker A L, Jaspan J B, Haines N W, Hatfield G E, Krager P S, Schneider J F
Gastroenterology. 1981 Jun;80(6):1410-4.
A randomized, double-blind, controlled trial of insulin and glucagon infusion was conducted in 50 patients with acute alcoholic hepatitis. Twenty-five treatment patients received 24 U regular insulin and 2.4 mg glucagon over 12 h daily for 3 wk. Twenty-five control patients received 200 ml dextrose solution in identical bottles over the same time period. Six control and 2 treatment patients died from liver failure during study, and another treatment patient died from hypoglycemia. In the 34 patients with prothrombin times greater than 3 s prolonged, fewer deaths occurred among the insulin- and glucagon-infused patients (p less than 0.10). Clinical features of liver disease on entry into the study were similar in the two groups, and total serum bilirubin and prothrombin time improved more rapidly in the treatment group (p less than 0.05). Insulin and glucagon infusion is a promising treatment of alcoholic hepatitis and merits further study in the most severely ill patients.
对50例急性酒精性肝炎患者进行了一项胰岛素和胰高血糖素输注的随机、双盲、对照试验。25例治疗患者每天在12小时内接受24单位普通胰岛素和2.4毫克胰高血糖素，共3周。25例对照患者在相同时间段内接受相同瓶子中的200毫升葡萄糖溶液。研究期间，6例对照患者和2例治疗患者死于肝功能衰竭，另有1例治疗患者死于低血糖。在凝血酶原时间延长超过3秒的34例患者中，接受胰岛素和胰高血糖素输注的患者死亡人数较少（p<0.10）。两组患者进入研究时肝病的临床特征相似，治疗组总血清胆红素和凝血酶原时间改善更快（p<0.05）。胰岛素和胰高血糖素输注是酒精性肝炎的一种有前景的治疗方法，值得在病情最严重的患者中进一步研究。
