Academy of Scientific and Innovative Research, Ghaziabad 201002, India.
Org Lett. 2020 Dec 4;22(23):9258-9262. doi: 10.1021/acs.orglett.0c03486. Epub 2020 Nov 17.
We herein report a chemo- and regioselective 6- catalytic cyclization of Ugi adducts N-substituted 2-alkynamides to access functionalized morpholinone glycoconjugates in the presence of triphenylphosphine. This array allows an interesting multicomponent access to a library of functionalized morpholinone glycoconjugates under mild reaction conditions with regeneration of catalyst triphenylphosphine, supported by P nuclear magnetic resonance studies. Density functional theory shows the 6- oxocyclization pathway is preferred, which supports our experimental observation.
我们在此报告了在三苯基膦存在下，Ugi 加合物 N-取代的 2-炔酰胺的化学和区域选择性 6-催化环化，以在温和的反应条件下，通过 P 核磁共振研究支持催化剂三苯基膦的再生，获得功能化吗啉酮糖缀合物的文库。密度泛函理论表明 6-氧环化途径是有利的，这支持了我们的实验观察。
