Lin Bohong, Ruan Yaoping, Hou Qi, Yuan Zhijun, Liang Yunshi, Zhang Jing
Artemisinin Research Center and The First Affiliated Hospital, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou 510405, China.
Org Biomol Chem. 2024 Jul 10;22(27):5585-5590. doi: 10.1039/d4ob00579a.
A highly regioselective 5- cyclization of aromatic -propargyloxycarbonyl guanidines was developed an Ag(I)-catalyzed intramolecular hydroamination reaction. This method features a fast reaction rate and mild reaction conditions. Furthermore, it was extended to access halogenated analogues a one-pot Ag(I)-catalyzed bromocyclization reaction or an I-mediated iodocyclization reaction with high / selectivity.
通过银（I）催化的分子内氢胺化反应，开发了一种高度区域选择性的芳基 - 炔丙氧基羰基胍的5 - 环化反应。该方法具有反应速率快、反应条件温和的特点。此外，通过一锅法银（I）催化的溴环化反应或碘介导的碘环化反应，以高区域/立体选择性扩展到制备卤代类似物。
