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适应不良的情绪调节特征预示着皮质边缘系统从心理社会压力中恢复的改变。

Maladaptive emotion regulation traits predict altered corticolimbic recovery from psychosocial stress.

机构信息

Psychiatry Department, Faculty of Medicine, University of Geneva, Campus Biotech, 1202 Geneva, Switzerland.

Psychiatry Department, Faculty of Medicine, University of Geneva, Campus Biotech, 1202 Geneva, Switzerland; Neuroscience Department, Laboratory for Behavioral Neurology and Imaging of Cognition, Campus Biotech, 1202 Geneva, Switzerland.

出版信息

J Affect Disord. 2021 Feb 1;280(Pt A):54-63. doi: 10.1016/j.jad.2020.09.122. Epub 2020 Oct 6.

Abstract

BACKGROUND

Adaptive recovery from stress promotes healthy cognitive affective functioning, whereas maladaptive recovery is linked to poor psychological outcomes. Neural regions, like the anterior cingulate and hippocampus, play critical roles in psychosocial stress responding and serve as hubs in the corticolimbic neural system. To date, however, it is unknown how cognitive emotion regulation traits (cER), adaptive and maladaptive, influence corticolimbic stress recovery. Here, we examined acute psychosocial stress neural recovery, accounting for cER.

METHODS

Functional neuroimaging data were collected while forty-seven healthy participants performed blocks of challenging, time-sensitive, mental calculations. Participants immediately received performance feedback (positive/negative/neutral) and their ranking, relative to fictitious peers. Participants rested for 90 seconds after each feedback, allowing for a neural stress recovery period. Collected before scanning, cER scores were correlated with neural activity during each recovery condition.

RESULTS

Negative feedback recovery yielded increased activity within the dorsomedial prefrontal cortex and amygdala, but this effect was ultimately explained by maladaptive cER (M-cER), like rumination. Isolating positive after-effects (i.e. positive > negative recovery) yielded a significant positive correlation between M-cER and the anterior cingulate, anterior insula, hippocampus, and striatum.

CONCLUSIONS

We provide first evidence of M-cER to predict altered neural recovery from positive stress within corticolimbic regions. Positive feedback may be potentially threatening to individuals with poor stress regulation. Identifying positive stress-induced activation patterns in corticolimbic neural networks linked to M-cER creates the possibility to identify these neural responses as risk factors for social-emotional dysregulation subsequent to rewarding social information, often witnessed in affective disorders, like depression.

摘要

背景

适应压力后的恢复有助于健康的认知情感功能,而适应不良的恢复则与不良的心理结果有关。神经区域,如前扣带和海马体,在心理社会应激反应中起着关键作用,是皮质边缘神经系统的枢纽。然而,迄今为止,尚不清楚认知情绪调节特征(cER),适应性和适应性不良,如何影响皮质边缘压力恢复。在这里,我们研究了急性心理社会应激神经恢复,考虑到 cER。

方法

在 47 名健康参与者进行具有挑战性、时间敏感的心理计算块时,收集功能神经影像学数据。参与者立即收到绩效反馈(正面/负面/中性)和他们相对于虚构同伴的排名。参与者在每次反馈后休息 90 秒,为神经压力恢复期留出时间。在扫描前收集的 cER 分数与每个恢复条件下的神经活动相关。

结果

负反馈恢复导致背内侧前额叶皮层和杏仁核的活动增加,但这种影响最终可以用适应性较差的 cER(M-cER),如沉思来解释。分离正后效(即正>负恢复),在 M-cER 与前扣带、前岛叶、海马体和纹状体之间产生了显著的正相关。

结论

我们首次提供了 M-cER 预测皮质边缘区域内正应激后神经恢复的证据。对压力调节能力差的个体来说,正反馈可能是潜在的威胁。识别与 M-cER 相关的皮质边缘神经网络中积极应激诱导的激活模式,为识别这些神经反应作为奖赏社会信息后社会情感失调的风险因素创造了可能性,这种反应经常在情感障碍中出现,如抑郁症。

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