Makepeace A R, Fermont D C, Bennett M H
Meyerstein Institute of Radiotherapy and Oncology, Middlesex Hospital, London.
J Laryngol Otol. 1987 Nov;101(11):1151-8. doi: 10.1017/s002221510010341x.
Over the 27-year period from 1954-1981, 51 patients with non-Hodgkin's lymphoma arising in the tonsil were treated at the Regional Radiotherapy Centre, Mount Vernon Hospital. The original biopsy material was reviewed in each case and reclassified using the British National Lymphoma Investigation criteria. Grade 2 non-Hodgkin's lymphoma was reported in 80 per cent of cases. Ninety per cent of patients presented in stages IE or IIE and were treated with radical local radiotherapy. A 5-year survival of 51 per cent was achieved and a 5-year relapse-free survival of 35 per cent. Stage IE patients had a statistically significant survival advantage compared to stage IIE. Sixty-one per cent of patients relapsed, of whom 74 per cent died from active lymphoma. The abdomen was the most frequent site for relapse with involvement of both nodal and extranodal sites.
在1954年至1981年的27年期间，弗农山医院地区放疗中心对51例扁桃体非霍奇金淋巴瘤患者进行了治疗。对每例患者的原始活检材料进行了复查，并根据英国国家淋巴瘤调查标准重新分类。80%的病例报告为2级非霍奇金淋巴瘤。90%的患者表现为IE期或IIE期，并接受了根治性局部放疗。5年生存率为51%，5年无复发生存率为35%。与IIE期患者相比，IE期患者具有统计学上显著的生存优势。61%的患者复发，其中74%死于活动性淋巴瘤。腹部是最常见的复发部位，包括淋巴结和结外部位受累。
