Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland,
Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland.
Dermatology. 2021;237(5):733-739. doi: 10.1159/000510689. Epub 2020 Nov 17.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. An important role of innate immune dysregulation in the pathogenesis of HS has been highlighted. S100A7 (psoriasin) is an innate, antimicrobial protein that exerts proinflammatory and chemotactic action.
The objective of the study was to investigate serum concentrations of S100A7 in individuals with HS as compared to healthy controls. Further, we evaluated the expression of S100A7 in lesional HS skin as compared to perilesional (clinically uninvolved) HS skin and normal skin.
Serum concentrations of S100A7 were evaluated with a commercially available ELISA kit. The expression of S100A7 in the skin was assessed using qRT-PCR and immunofluorescence staining.
We found increased expression of S100A7 in lesional HS skin as compared to perilesional HS skin (p = 0.0017). The expression of S100A7 in lesional HS skin was positively associated with serum C-reactive protein concentration and the severity of disease according to Hurley staging. The serum concentration of S100A7 in individuals with HS was decreased as compared to healthy controls and patients with psoriasis.
Upregulated in lesional HS skin, S100A7 may enhance the inflammatory process and contribute to the HS pathogenesis.
化脓性汗腺炎（HS）是一种慢性炎症性皮肤病。先天免疫失调在 HS 的发病机制中起着重要作用。S100A7（银屑病素）是一种先天的、抗菌蛋白，具有促炎和趋化作用。
本研究旨在比较 HS 患者与健康对照组的血清 S100A7 浓度。此外，我们还评估了 S100A7 在病变 HS 皮肤与病变周围（临床未受累）HS 皮肤和正常皮肤中的表达。
使用商业 ELISA 试剂盒评估血清 S100A7 浓度。使用 qRT-PCR 和免疫荧光染色评估 S100A7 在皮肤中的表达。
与病变周围 HS 皮肤相比，我们发现病变 HS 皮肤中 S100A7 的表达增加（p = 0.0017）。病变 HS 皮肤中 S100A7 的表达与血清 C-反应蛋白浓度和 Hurley 分期评估的疾病严重程度呈正相关。与健康对照组和银屑病患者相比，HS 患者的血清 S100A7 浓度降低。
S100A7 在病变 HS 皮肤中上调，可能增强炎症过程并有助于 HS 的发病机制。
