Otlewska-Szpotowicz Agnieszka, Baran Wojciech, Woźniak Zdzisław, Szepietowski Jacek, Batycka-Baran Aleksandra
Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Wroclaw, Poland.
Department of Clinical and Experimental Pathology, Wroclaw Medical University, Wroclaw, Poland.
Postepy Dermatol Alergol. 2024 Aug;41(4):364-371. doi: 10.5114/ada.2024.142179. Epub 2024 Aug 12.
Lichen planopilaris (LPP) is an inflammatory, primary scarring alopecia, however its pathogenesis is not completely elucidated. S100A7 is a multifunctional, antimicrobial protein with proinflammatory properties. Interleukin-17 (IL-17) is implicated in the development of various autoimmune skin diseases.
To determine the tissue expression of S100A7, S100A4 and IL-17 in LPP.
The immunohistochemical analysis was performed on biopsy specimens obtained from individuals with histologically confirmed lichen planopilaris ( = 23), alopecia areata (AA) ( = 11), and healthy controls ( = 14). The expression was evaluated using Zeiss Axio Imager A2 light microscope.
The number of cells showing S100A7 expression was significantly higher in LPP lesional skin compared to AA lesional skin ( = 0.0002) and normal skin of healthy controls ( < 0.0001). The number of cells showing IL-17 expression was significantly higher in LPP lesional skin compared to normal skin of healthy controls ( < 0.0001) and the number of cells showing IL-17 expression was significantly higher in AA lesional skin compared to normal skin of healthy controls ( < 0.0001). The number of cells showing IL-17 expression was not significantly different in LPP lesional skin and in AA lesional skin ( > 0.05). The number of cells showing S100A4 expression was not significantly different in LPP lesional skin, AA lesional skin and in normal skin of healthy controls.
The results of our study suggest the possible role of S100A7 and IL-17 in the pathogenesis of LPP.
扁平苔藓样毛发角化病（LPP）是一种炎症性原发性瘢痕性脱发，但其发病机制尚未完全阐明。S100A7是一种具有促炎特性的多功能抗菌蛋白。白细胞介素-17（IL-17）与多种自身免疫性皮肤病的发生有关。
确定S100A7、S100A4和IL-17在LPP中的组织表达情况。
对经组织学确诊为扁平苔藓样毛发角化病（n = 23）、斑秃（AA）（n = 11）的个体以及健康对照者（n = 14）的活检标本进行免疫组织化学分析。使用蔡司Axio Imager A2光学显微镜评估表达情况。
与AA皮损皮肤（P = 0.0002）和健康对照者的正常皮肤（P < 0.0001）相比，LPP皮损皮肤中显示S100A7表达的细胞数量显著更高。与健康对照者的正常皮肤相比，LPP皮损皮肤中显示IL-17表达的细胞数量显著更高（P < 0.0001），与健康对照者的正常皮肤相比，AA皮损皮肤中显示IL-17表达的细胞数量也显著更高（P < 0.0001）。LPP皮损皮肤和AA皮损皮肤中显示IL-17表达的细胞数量无显著差异（P > 0.05）。LPP皮损皮肤、AA皮损皮肤和健康对照者的正常皮肤中显示S100A4表达的细胞数量无显著差异。
我们的研究结果提示S100A7和IL-17在LPP发病机制中可能起作用。
