Riche Cezar V W, Cassol Renato, Pasqualotto Alessandro C
Hospital Ernesto Dornelles, Porto Alegre 90160-092, Brazil.
School of Medicine, Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre 90050-170, Brazil.
J Fungi (Basel). 2020 Nov 13;6(4):286. doi: 10.3390/jof6040286.
Corticosteroids have potent anti-inflammatory and immunosuppressive effects. Recently, these medications have gained importance in the treatment of severe COVID-19. Here we present data demonstrating a marked (10-fold) increase in frequency of candidemia in hospitalized patients with COVID-19 receiving corticosteroids in Brazil. Overall mortality was 72.7%, despite antifungal therapy. Physicians should be aware of the potential risk for candidemia among severely ill COVID-19 patients receiving high-doses of corticosteroids.
皮质类固醇具有强大的抗炎和免疫抑制作用。最近,这些药物在重症 COVID-19 的治疗中变得越发重要。在此,我们展示的数据表明,在巴西接受皮质类固醇治疗的 COVID-19 住院患者中,念珠菌血症的发生率显著(10 倍)增加。尽管进行了抗真菌治疗,总体死亡率仍为 72.7%。医生应意识到接受高剂量皮质类固醇治疗的重症 COVID-19 患者发生念珠菌血症的潜在风险。