Al Dhaheri Fatima, Thomsen Jens, Everett Dean, Denning David W
Department of Pediatrics, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.
Department of Public Health and Epidemiology, Khalifa University, Abu Dhabi P.O. Box 127788, United Arab Emirates.
J Fungi (Basel). 2024 May 15;10(5):353. doi: 10.3390/jof10050353.
The United Arab Emirates has very little data on the incidence or prevalence of fungal diseases. Using total and underlying disease risk populations and likely affected proportions, we have modelled the burden of fungal disease for the first time. The most prevalent serious fungal conditions are recurrent vulvovaginitis (190,000 affected) and fungal asthma (34,000 affected). Given the UAE's low prevalence of HIV, we estimate an at-risk population of 204 with respect to serious fungal infections with cryptococcal meningitis estimated at 2 cases annually, 15 cases of pneumonia (PCP) annually, and 20 cases of esophageal candidiasis in the HIV population. PCP incidence in non-HIV patients is estimated at 150 cases annually. Likewise, with the same low prevalence of tuberculosis in the country, we estimate a total chronic pulmonary aspergillosis prevalence of 1002 cases. The estimated annual incidence of invasive aspergillosis is 505 patients, based on local data on rates of malignancy, solid organ transplantation, and chronic obstructive pulmonary disease (5.9 per 100,000). Based on the 2022 annual report of the UAE's national surveillance database, candidaemia annual incidence is 1090 (11.8/100,000), of which 49.2% occurs in intensive care. Fungal diseases affect ~228,695 (2.46%) of the population in the UAE.
阿拉伯联合酋长国关于真菌疾病发病率或患病率的数据非常少。我们利用总体和潜在疾病风险人群以及可能受影响的比例，首次对真菌疾病的负担进行了建模。最常见的严重真菌病是复发性外阴阴道炎（约190,000例患者）和真菌性哮喘（约34,000例患者）。鉴于阿联酋艾滋病毒感染率较低，我们估计有204人面临严重真菌感染的风险，其中估计每年有2例隐球菌性脑膜炎、15例肺炎（肺孢子菌肺炎）以及20例艾滋病毒感染者发生食管念珠菌病。估计非艾滋病毒患者中肺孢子菌肺炎的年发病率为150例。同样，由于该国结核病患病率也很低，我们估计慢性肺曲霉病的总患病率为1002例。根据当地关于恶性肿瘤、实体器官移植和慢性阻塞性肺疾病的发病率数据（每10万人中有5.9例），侵袭性曲霉病的估计年发病率为505例患者。根据阿联酋国家监测数据库2022年年度报告，念珠菌血症的年发病率为1090例（11.8/10万），其中49.2%发生在重症监护病房。真菌疾病影响阿联酋约228,695人（占人口的2.46%）。
