USF Genomics & College of Public Health, University of South Florida, Tampa, FL, USA.
Department of Biostatistics and Data Science, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Genome Biol. 2020 Nov 17;21(1):280. doi: 10.1186/s13059-020-02196-9.
Inferring the demographic histories of populations has wide applications in population, ecological, and conservation genomics. We present Stairway Plot 2, a cross-platform program package for this task using SNP frequency spectra. It is based on a nonparametric method with the capability of handling folded SNP frequency spectra (that is, when the ancestral alleles of the SNPs are unknown) of thousands of samples produced with genotyping-by-sequencing technologies; therefore, it is particularly suitable for nonmodel organisms.
推断群体的人口历史在人口学、生态学和保护基因组学中有着广泛的应用。我们介绍了 Stairway Plot 2，这是一个使用 SNP 频率谱进行此任务的跨平台程序包。它基于一种非参数方法，具有处理数千个样本的折叠 SNP 频率谱（即当 SNP 的祖先等位基因未知时）的能力，这些样本是使用测序技术进行基因分型产生的；因此，它特别适用于非模式生物。
