Klingenstein Annemarie, Samel Christina, Garip-Kuebler Aylin, Priglinger Siegfried G, Foerster Paul I
Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
Institute of Medical Statistics and Computational Biology, Faculty of Medicine, University of Cologne, Cologne, Germany.
Clin Ophthalmol. 2020 Nov 9;14:3813-3819. doi: 10.2147/OPTH.S276848. eCollection 2020.
To assess a profile of uveal melanoma patients at risk of requiring active psycho-oncological intervention by employing the National Comprehensive Cancer Network (NCCN) distress thermometer.
Multivariate correlation and multiple linear regression analysis of data collected retrospectively from 106 consecutive patients suffering from uveal melanoma.
Distress levels correlated with practical (p = 0.01), emotional (p = 0.003) and physical problems (p = 0.001) as well as the total number of issues reported (p < 0.001; ANOVA, respectively). Emotional issues added up to 39% of influence on distress levels. Nervousness, worry and sadness as the most important emotional issues tested correlated significantly with anatomic stage, tumor T-category, metastatic status and time after primary diagnosis and were present more frequently in patients with higher distress levels (p < 0.001, p = 0.002, p = 0.004, respectively, Fisher's exact test). Pre-existing psycho-oncological support was more frequent in metastatic patients and patients with higher anatomic stage tumors (p = 0.008 and p = 0.003; Fisher's exact test).
The distress thermometer proved to be useful for rapid assessment of patients requiring active intervention. A higher number of distress items recorded correlated with elevated distress levels. Emotional issues were responsible for the majority of problems. A typical patient profile at risk of developing distress requiring close attention of caregivers includes high anatomic stage, high T-category, presence of metastases and early follow-up. Correct diagnosis and interpretation of distress-levels should help improve the quality of life of uveal melanoma survivors.
Not applicable.
通过使用美国国立综合癌症网络（NCCN）苦恼温度计，评估有需要积极心理肿瘤学干预风险的葡萄膜黑色素瘤患者概况。
对106例连续的葡萄膜黑色素瘤患者回顾性收集的数据进行多变量相关性和多元线性回归分析。
苦恼水平与实际问题（p = 0.01）、情绪问题（p = 0.003）、身体问题（p = 0.001）以及报告的问题总数（p < 0.001；方差分析）相关。情绪问题对苦恼水平的影响总计达39%。测试中最重要的情绪问题——紧张、担忧和悲伤，与解剖分期、肿瘤T分类、转移状态及初次诊断后的时间显著相关，且在苦恼水平较高的患者中更常见（分别为p < 0.001、p = 0.002、p = 0.004，Fisher精确检验）。既往有心理肿瘤学支持在转移患者和解剖分期较高的肿瘤患者中更常见（p = 0.008和p = 0.003；Fisher精确检验）。
苦恼温度计被证明对快速评估需要积极干预的患者有用。记录的苦恼项目数量越多，苦恼水平越高。情绪问题是大多数问题的原因。有发生苦恼风险、需要护理人员密切关注的典型患者概况包括高解剖分期、高T分类、存在转移及早期随访。苦恼水平的正确诊断和解读应有助于改善葡萄膜黑色素瘤幸存者的生活质量。
不适用。
