Primary pulmonary lymphoma demonstration of monoclonality by lymphocyte surface marker study.

We present here a case of small lymphocytic B cell lymphoma of the lung which developed in a 51-year-old Japanese man who was asymptomatic while his chest X-rays revealed slowly progressive infiltrative shadows. Findings of transbronchial lung biopsy suggested lymphoproliferative disorders and the diagnosis of B-cell lymphoma of the lung was established with lung specimen obtained by an open lung biopsy and through demonstration of monoclonal surface markers on lymphocytes in fresh frozen lung sections. Diagnostic value of surface marker analysis is emphasized.