Gephardt G N, Tubbs R R, Liu A C, Petras R E, Ahmad M, Golish J A, Tomashefski J F
Chest. 1986 Apr;89(4):545-50. doi: 10.1378/chest.89.4.545.
Seven cases of lymphoid neoplasms presenting in the lung were evaluated by immunohistology for T and B cell antigens and immunoglobulin light chains in frozen tissue sections. Although follow-up was short or inconclusive in some patients with lymphoma and pseudolymphoma, it was concluded that evaluation of T and B cell antigens and immunoglobulin light chains in frozen tissue is helpful in classifying lymphocytic neoplasms, especially in cases without definite cytologic evidence of malignancy. As demonstrated in two additional cases, lymphocyte/leukocyte markers in paraffin-embedded tissue are important in the differential diagnosis of lesions with cytologic features of malignancy.
对7例肺部出现的淋巴样肿瘤进行了免疫组织学评估，检测冷冻组织切片中的T和B细胞抗原以及免疫球蛋白轻链。尽管部分淋巴瘤和假性淋巴瘤患者的随访时间较短或结果不明确，但得出的结论是，评估冷冻组织中的T和B细胞抗原以及免疫球蛋白轻链有助于对淋巴细胞性肿瘤进行分类，尤其是在没有明确恶性细胞学证据的病例中。如另外2例所示，石蜡包埋组织中的淋巴细胞/白细胞标志物在具有恶性细胞学特征的病变鉴别诊断中很重要。
