Sun Min, Zhang Hongming, Chen Xinjian, Zhang Qimi
Department of Electronic and Information Engineering, Wenzheng College of Soochow University, Suzhou, Jiangsu, China.
Department of Electronic Engineering, Jiangsu Vocational College of Electronics and Information, Huaian, Jiangsu, China.
J Ophthalmol. 2020 Nov 4;2020:8896114. doi: 10.1155/2020/8896114. eCollection 2020.
To quantitatively investigate the macular retinal light reflection characteristic using optical property indices derived from spectral-domain optical coherence tomography (SD-OCT) scans with depth attenuation compensation for pituitary adenoma.
This study included 38 patients (mean age 44.66 ± 13.77 years old) with diagnosis of pituitary adenoma and 43 age-matched controls. All SD-OCT scans were light attenuation compensated by a depth-resolved model. Attenuation coefficient, the corrected intensity, and the retinal layer thickness were deduced for macular retinal nerve fiber layer (RNFL) and ganglion cell layer combined with inner plexiform layer (GCIPL), as well as comparing between patients and controls by statistical methods.
Attenuation coefficients of RNFL and GCIPL among patients were significantly lower compared to the controls with values equal to or less than 0.001. The mean values of the corrected optical intensity were decreased in the patients without universally significant differences. Significant decreases in thickness existing in the RNFL of patients, especially in the superonasal (SN) quadrant and inferonasal (IN) quadrant (decrease ratio = 9.64% and 13.02%, both with < 0.001). The thickness of RNFL was significantly associated with the attenuation coefficient (standardized beta = 0.335, =0.002). The performances of attenuation coefficient were better than the corrected optical intensity and the thickness (the values of the areas under the receiver operating characteristic curves = 0.751 and 0.758, both with < 0.001) in discriminating pituitary adenoma patients from controls.
The retinal light reflection characteristics were debilitated in patients with pituitary adenoma. The potential of attenuation coefficients of RNFL and GCIPL in distinguishing patients with pituitary adenoma from controls was validated by the comparison of the derived optical property indices.
利用从光谱域光学相干断层扫描（SD-OCT）扫描中获得的光学特性指数，对垂体腺瘤进行深度衰减补偿，定量研究黄斑区视网膜光反射特征。
本研究纳入38例诊断为垂体腺瘤的患者（平均年龄44.66±13.77岁）和43例年龄匹配的对照者。所有SD-OCT扫描均采用深度分辨模型进行光衰减补偿。推导黄斑区视网膜神经纤维层（RNFL）和神经节细胞层与内丛状层联合层（GCIPL）的衰减系数、校正强度和视网膜层厚度，并通过统计学方法比较患者与对照者之间的差异。
患者组RNFL和GCIPL的衰减系数显著低于对照组，P值均等于或小于0.001。校正后的光强度平均值在患者中降低，但无普遍显著差异。患者RNFL厚度显著降低，尤其是在鼻上（SN）象限和鼻下（IN）象限（降低率分别为9.64%和13.02%，P均<0.001）。RNFL厚度与衰减系数显著相关（标准化β=0.335，P=0.002）。在区分垂体腺瘤患者与对照者方面，衰减系数的表现优于校正后的光强度和厚度（受试者工作特征曲线下面积值分别为0.751和0.758，P均<0.001）。
垂体腺瘤患者的视网膜光反射特征减弱。通过比较推导的光学特性指数，验证了RNFL和GCIPL衰减系数在区分垂体腺瘤患者与对照者方面的潜力。
