Vermeer K A, Mo J, Weda J J A, Lemij H G, de Boer J F
Rotterdam Ophthalmic Institute, Rotterdam Eye Hospital, P.O. Box 70030, 3000 LM Rotterdam, The Netherlands.
LaserLaB Amsterdam, VU University De Boelelaan 1081, 1081 HV Amsterdam, The Netherlands.
Biomed Opt Express. 2013 Dec 23;5(1):322-37. doi: 10.1364/BOE.5.000322.
We present a method, based on a single scattering model, to calculate the attenuation coefficient of each pixel in optical coherence tomography (OCT) depth profiles. Numerical simulations were used to determine the model's response to different depths and attenuation coefficients. Experiments were performed on uniform and layered phantoms with varying attenuation coefficients. They were measured by a 1300 nm OCT system and their attenuation coefficients were evaluated by our proposed method and by fitting the OCT slope as the gold standard. Both methods showed largely consistent results for the uniform phantoms. On the layered phantom, only our proposed method accurately estimated the attenuation coefficients. For all phantoms, the proposed method largely reduced the variability of the estimated attenuation coefficients. The method was illustrated on an in-vivo retinal OCT scan, effectively removing common imaging artifacts such as shadowing. By providing localized, per-pixel attenuation coefficients, this method enables tissue characterization based on attenuation coefficient estimates from OCT data.
我们提出了一种基于单散射模型的方法，用于计算光学相干断层扫描（OCT）深度剖面图中每个像素的衰减系数。通过数值模拟来确定该模型对不同深度和衰减系数的响应。对具有不同衰减系数的均匀和分层体模进行了实验。使用1300 nm的OCT系统对它们进行测量，并通过我们提出的方法以及将OCT斜率拟合作为金标准来评估它们的衰减系数。对于均匀体模，两种方法的结果在很大程度上是一致的。在分层体模上，只有我们提出的方法能够准确估计衰减系数。对于所有体模，所提出的方法在很大程度上降低了估计衰减系数的变异性。该方法在体内视网膜OCT扫描中得到了验证，有效去除了诸如阴影等常见成像伪影。通过提供局部的、逐像素的衰减系数，该方法能够基于从OCT数据估计的衰减系数来实现组织表征。
