Azariadis Kalliopi, Giannoulis George, Gabeta Stella, Michail Anastasia, Zachou Kalliopi, Dalekos George N
Department of Medicine and Research Laboratory of Internal Medicine, National Expertise Center of Greece in Autoimmune Liver Diseases, General University Hospital of Larissa, Larissa 41110, Greece.
Institute of Internal Medicine and Hepatology, Larissa 41447, Greece.
Case Rep Infect Dis. 2020 Nov 4;2020:8854868. doi: 10.1155/2020/8854868. eCollection 2020.
Acute rheumatic fever (ARF) is the immune-mediated sequelae of untreated group-A streptococcal infection. In this regard, rheumatic heart disease is the most prominent manifestation with devastating long-term complications. In the postantibiotic era, ARF is extremely rare in high-income countries; thus, its diagnosis might escape the clinicians' notice. However, its incidence remains high not only in certain low- and middle-income regions with poor public health systems but also in socioeconomically vulnerable populations residing in high-income countries. Herein, we report two cases of ARF in young immigrant adults in order to highlight the need for increased clinical suspicion to establish a prompt and timely diagnosis of ARF and describe in detail its differential diagnosis and approach to treatment.
急性风湿热（ARF）是未经治疗的A组链球菌感染的免疫介导后遗症。就此而言，风湿性心脏病是最突出的表现，伴有严重的长期并发症。在抗生素时代之后，ARF在高收入国家极为罕见；因此，其诊断可能会被临床医生忽视。然而，不仅在公共卫生系统较差的某些低收入和中等收入地区，而且在居住在高收入国家的社会经济弱势群体中，其发病率仍然很高。在此，我们报告两例年轻移民成年人的ARF病例，以强调需要提高临床怀疑度，以便及时准确地诊断ARF，并详细描述其鉴别诊断和治疗方法。
