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减少阿片类药物处方用量可降低其消耗量,且不会对全髋关节和膝关节置换术后患者报告的疼痛干扰评分产生不利影响。

Reducing Opioid Prescriptions Lowers Consumption Without Detriment to Patient-Reported Pain Interference Scores After Total Hip and Knee Arthroplasties.

作者信息

Barnes Ryan H, Shapiro Joshua A, Woody Nathan, Chen Fei, Olcott Christopher W, Del Gaizo Daniel J

机构信息

Department of Orthopaedics, University of North Carolina at Chapel Hill Hospital, Chapel Hill, NC, USA.

Department of Anesthesiology, University of North Carolina at Chapel Hill Hospital, Chapel Hill, NC, USA.

出版信息

Arthroplast Today. 2020 Nov 6;6(4):919-924. doi: 10.1016/j.artd.2020.09.017. eCollection 2020 Dec.

Abstract

BACKGROUND

Opioid addiction is endemic in the United States. We developed a standardized opioid-prescribing schedule (SOPS) after total hip arthroplasty (THA) and total knee arthroplasty (TKA) and evaluated opioid usage alongside Patient-Reported Outcomes Measurement Information System (PROMIS) pain interference scores. We hypothesized that opioid usage would be less than prescribed and reducing prescription would decrease consumption without negatively impacting the PROMIS scores.

METHODS

A prospective observational study was performed on all patients undergoing primary THA and TKA from April 7, 2018, to August 10, 2019. Opioid consumption and pain interference were determined 2 weeks after discharge via telephone and email surveys. SOPSs were implemented during the study. Outcomes were compared in patients before and after the SOPS.

RESULTS

A total of 715 patients met inclusion criteria; 201 patients completed surveys. Before the SOPS, the mean opioid prescription was 81.2 ± 15.3 tablets for THA and 82.9 ± 10.6 for TKA. The mean usage was 35.1 ± 29.4 tablets and 35.4 ± 33.4, respectively. After the SOPS, the mean usage decreased to 19.4 ± 16.8 ( = .04) and 31.6 ± 20.9 ( = .52), respectively. After implementation of a second SOPS for THA, the mean number of tablets consumed was 21.5 ± 18.6 ( = .05 compared with pre-SOPS). The PROMIS 6B responses in patients who underwent THA demonstrated no significant changes. PROMIS 6B responses for TKA showed an increase in interference with recreational activities ( = .04) and tasks away from home ( = .04), but otherwise had no significant impact on reported scores.

CONCLUSIONS

Implementation of the SOPS reduced postoperative opioid prescription and consumption without significantly impacting the reported pain interference, supporting the need to decrease opioid prescription after THA and TKA.

摘要

背景

阿片类药物成瘾在美国呈地方性流行。我们制定了全髋关节置换术(THA)和全膝关节置换术(TKA)后的标准化阿片类药物处方方案(SOPS),并结合患者报告的结局测量信息系统(PROMIS)疼痛干扰评分评估阿片类药物的使用情况。我们假设阿片类药物的使用量将低于处方量,减少处方量将减少消费量,且不会对PROMIS评分产生负面影响。

方法

对2018年4月7日至2019年8月10日期间接受初次THA和TKA的所有患者进行了一项前瞻性观察研究。出院2周后通过电话和电子邮件调查确定阿片类药物消费量和疼痛干扰情况。在研究期间实施了SOPS。对SOPS实施前后的患者结局进行了比较。

结果

共有715例患者符合纳入标准;201例患者完成了调查。在SOPS实施前,THA的平均阿片类药物处方量为81.2±15.3片,TKA为82.9±10.6片。平均使用量分别为35.1±29.4片和35.4±33.4片。在SOPS实施后,平均使用量分别降至19.4±16.8片(P=0.04)和31.6±20.9片(P=0.52)。对THA实施第二个SOPS后,平均消费片数为21.5±18.6片(与SOPS实施前相比,P=0.05)。接受THA的患者的PROMIS 6B反应无显著变化。TKA的PROMIS 6B反应显示,对娱乐活动的干扰增加(P=0.04),对离家任务的干扰增加(P=0.04),但对报告的评分没有其他显著影响。

结论

SOPS的实施减少了术后阿片类药物的处方量和消费量,且对报告的疼痛干扰没有显著影响,支持在THA和TKA后减少阿片类药物处方的必要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5674/7653012/e319fe332855/gr1.jpg

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