Rockwood Kenneth, Andrew Melissa K, Aubertin-Leheudre Mylène, Belleville Sylvie, Bherer Louis, Bowles Susan K, Kehler D Scott, Lim Andrew, Middleton Laura, Phillips Natalie, Wallace Lindsay M K
Division of Geriatric Medicine Dalhousie University Halifax Nova Scotia Canada.
Département de Kinanthropologie Université du Québec à Montréal Montréal Québec Canada.
Alzheimers Dement (N Y). 2020 Nov 11;6(1):e12083. doi: 10.1002/trc2.12083. eCollection 2020.
The Fifth Canadian Consensus Conference on the Diagnosis and Treatment of Dementia (CCCDTD-5) was a year-long process to synthesize the best available evidence on several topics. Our group undertook evaluation of risk reduction, in eight domains: nutrition; physical activity; hearing; sleep; cognitive training and stimulation; social engagement and education; frailty; and medications. Here we describe the rationale for the undertaking and summarize the background evidence-this is also tabulated in the Appendix. We further comment specifically on the relationship between age and dementia, and offer some suggestions for how reducing the risk of dementia in the seventh decade and beyond might be considered if we are to improve prospects for prevention in the near term. We draw to attention that a well-specified model of success in dementia prevention need not equate to the elimination of cognitive impairment in late life.
第五届加拿大痴呆症诊断与治疗共识会议（CCCDTD - 5）是一个为期一年的过程，旨在综合多个主题的最佳现有证据。我们的小组对八个领域的风险降低进行了评估：营养；身体活动；听力；睡眠；认知训练与刺激；社交参与和教育；虚弱；以及药物治疗。在此，我们描述了这项工作的基本原理，并总结了背景证据——附录中也以表格形式列出了这些内容。我们还特别评论了年龄与痴呆症之间的关系，并就如果我们要在短期内改善预防前景，如何考虑降低七十岁及以上人群患痴呆症风险提出了一些建议。我们提请注意，一个明确界定的痴呆症预防成功模式不必等同于消除晚年的认知障碍。
