与培养法相比，CB-核酸扩增检测法在诊断结核病中的有效性：来自印度南部一个城市地区的研究。
Validity of a CB-NAAT assay in diagnosing tuberculosis in comparison to culture: A study from an urban area of South India.
作者信息
Raj Aishwarya, Baliga Shrikala, Shenoy M Suchitra, Dhanashree B, Mithra P Prasanna, Nambiar Smitha K, Sharon Leesha
机构信息
Department of Biophysics, National Institute of Mental Health and Neuro Sciences (Institute of National Importance), Bengaluru, India.
Department of Microbiology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, India.
出版信息
J Clin Tuberc Other Mycobact Dis. 2020 Oct 28;21:100198. doi: 10.1016/j.jctube.2020.100198. eCollection 2020 Dec.
Abstract
•CB-NAAT performance compared in 831 suspected pulmonary and extrapulmonary suspected cases.•The conventional stained smear and CB-NAAT results were compared to the MGIT culture.•Sensitivity and specificity of CB-NAAT was 84.43% and 94.93%.•The rapid results from CB-NAAT confirms its use in the tuberculosis diagnostic algorithm.•The benefits of disease diagnosis and prevention outweighs the price tag of the CB-NAAT tests.•This is more so for the resource poor countries where the burden of the disease is high.
摘要
•在831例疑似肺结核和肺外结核病例中对CB-NAAT检测性能进行比较。
•将传统染色涂片和CB-NAAT检测结果与MGIT培养结果进行比较。
•CB-NAAT的敏感性和特异性分别为84.43%和94.93%。
•CB-NAAT的快速检测结果证实了其在结核病诊断流程中的应用价值。
•疾病诊断和预防的益处超过了CB-NAAT检测的成本。
•对于疾病负担较重的资源匮乏国家而言更是如此。
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