School of Social Work, Rutgers University, New Brunswick, NJ, USA.
Teachers College, Columbia University, New York, NY, USA.
AIDS Behav. 2021 Apr;25(4):1299-1305. doi: 10.1007/s10461-020-03095-7. Epub 2020 Nov 18.
Sexual minority men (SMM) remain at high risk of HIV infection in the United States, and for those in relationships, dyadic functioning may contextualize prevention decisions. Pre-exposure prophylaxis (PrEP) for HIV prevention was previously limited to tenofovir disoproxil fumarate/emtricitabine (TDF/FTC) until the FDA approved tenofovir alafenamide/FTC (TAF/FTC) for PrEP in 2019. Data regarding substance use, sexual behavior, holding an active PrEP prescription, and type of PrEP regimen (TDF/FTC versus TAF/FTC) were analyzed from a sample of 421 partnered SMM. The majority of the sample on PrEP reported a TDF/FTC prescription as opposed to TAF/FTC. However, SMM reported significantly better adherence to TAF/FTC than TDF/FTC in multivariable models. Novelty of TAF/FTC, treatment fatigue with TDF/FTC, and/or a belief in TAF/FTC's superior efficacy and mitigated side effects may be plausible contributing factors. More studies using objective adherence metrics and surveys are needed.
性少数群体男性（SMM）在美国仍然面临着感染 HIV 的高风险，对于那些处于伴侣关系中的人来说，双性关系的功能可能会影响预防决策。艾滋病毒预防的暴露前预防（PrEP）以前仅限于替诺福韦二吡呋酯/恩曲他滨（TDF/FTC），直到 2019 年 FDA 批准替诺福韦艾拉酚胺/恩曲他滨（TAF/FTC）用于 PrEP。从 421 名有伴侣关系的 SMM 样本中分析了与物质使用、性行为、持有有效 PrEP 处方以及 PrEP 方案类型（TDF/FTC 与 TAF/FTC）有关的数据。与 TAF/FTC 相比，大多数接受 PrEP 的样本报告使用的是 TDF/FTC 处方。然而，在多变量模型中，SMM 报告的 TAF/FTC 依从性明显好于 TDF/FTC。TAF/FTC 的新颖性、TDF/FTC 的治疗疲劳，以及/或对 TAF/FTC 更高疗效和减轻副作用的信念，可能是合理的促成因素。需要更多使用客观依从性指标和调查的研究。
