单核细胞 CD169 表达作为 2019 年冠状病毒病早期诊断的生物标志物。
Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019.
机构信息
Pathogenesis and Control of Chronic Infections, Montpellier University, INSERM, EFS, Montpellier, France.
INSERM U1175/IRD UMI 233, IRD, Montpellier University, Montpellier, France.
出版信息
J Infect Dis. 2021 Feb 24;223(4):562-567. doi: 10.1093/infdis/jiaa724.
Abstract
We assessed the expression of CD169, a type I interferon-inducible receptor, on monocytes (monocyte CD169 [mCD169]) in 53 adult patients admitted to the hospital during the coronavirus disease 2019 (COVID-19) outbreak for a suspicion of severe acute respiratory syndrome coronavirus 2 infection. Monocyte CD169 was strongly overexpressed in 30 of 32 (93.7%) confirmed COVID-19 cases, compared with 3 of 21 (14.3%) patients in whom the diagnosis of COVID-19 was finally ruled out. Monocyte CD169 was associated with the plasma interferon-alpha level and thrombocytopenia. Monocyte CD169 testing may be helpful for the rapid triage of suspected COVID-19 patients during an outbreak.
摘要
我们评估了 53 名在 2019 冠状病毒病（COVID-19）爆发期间因疑似严重急性呼吸综合征冠状病毒 2 感染而住院的成年患者单核细胞（单核细胞 CD169 [mCD169]）上 CD169 的表达。与最终排除 COVID-19 诊断的 21 名患者中的 3 名（14.3%）相比，32 例确诊 COVID-19 病例中有 30 例（93.7%）强烈过表达 CD169。单核细胞 CD169 与血浆干扰素-α水平和血小板减少症有关。单核细胞 CD169 检测可能有助于在疫情爆发期间快速分诊疑似 COVID-19 患者。
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