COVID-19 患者入住重症监护病房时的单核细胞 CD169 表达。
Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission.
机构信息
Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire d'Immunologie, Lyon, France.
EA 7426 Pathophysiology of Injury-Induced Immunosuppression, (Université Claude Bernard Lyon 1-Hospices Civils de Lyon-bioMérieux), Hôpital Edouard Herriot, Lyon, France.
出版信息
Cytometry A. 2021 May;99(5):466-471. doi: 10.1002/cyto.a.24315. Epub 2021 Feb 5.
Abstract
During the second surge of COVID-19 in France (fall 2020), we assessed the expression of monocyte CD169 (i.e., Siglec-1, one of the numerous IFN-stimulated genes) upon admission to intensive care units of 45 patients with RT-PCR-confirmed SARS-CoV2 pulmonary infection. Overall, CD169 expression was strongly induced on circulating monocytes of COVID-19 patients compared with healthy donors and patients with bacterial sepsis. Beyond its contribution at the emergency department, CD169 testing may be also helpful for patients' triage at the ICU to rapidly reinforce suspicion of COVID-19 etiology in patients with acute respiratory failure awaiting for PCR results for definitive diagnosis.
摘要
在法国 COVID-19 的第二次疫情高峰期（2020 年秋季），我们评估了 45 名经 RT-PCR 确诊的 SARS-CoV2 肺部感染患者入住重症监护病房时单核细胞 CD169（即 Siglec-1，众多 IFN 刺激基因之一）的表达情况。总体而言，与健康供体和细菌性败血症患者相比，COVID-19 患者循环单核细胞中 CD169 的表达被强烈诱导。除了在急诊部门的贡献外，CD169 检测对于 ICU 患者的分诊也可能有帮助，以便在等待 PCR 结果进行明确诊断的急性呼吸衰竭患者中，快速加强对 COVID-19 病因的怀疑。
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本文引用的文献
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