• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission.COVID-19 患者入住重症监护病房时的单核细胞 CD169 表达。
Cytometry A. 2021 May;99(5):466-471. doi: 10.1002/cyto.a.24315. Epub 2021 Feb 5.
2
CD169 and CD64 could help differentiate bacterial from CoVID-19 or other viral infections in the Emergency Department.CD169 和 CD64 有助于在急诊科区分细菌性和 COVID-19 或其他病毒性感染。
Cytometry A. 2021 May;99(5):435-445. doi: 10.1002/cyto.a.24314. Epub 2021 Feb 8.
3
Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019.单核细胞 CD169 表达作为 2019 年冠状病毒病早期诊断的生物标志物。
J Infect Dis. 2021 Feb 24;223(4):562-567. doi: 10.1093/infdis/jiaa724.
4
CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity.CD169/SIGLEC1在新冠病毒疾病（COVID-19）的循环单核细胞上表达，其表达水平与疾病严重程度相关。
Infection. 2021 Aug;49(4):757-762. doi: 10.1007/s15010-021-01606-9. Epub 2021 Apr 6.
5
Increased sCD163 and sCD14 Plasmatic Levels and Depletion of Peripheral Blood Pro-Inflammatory Monocytes, Myeloid and Plasmacytoid Dendritic Cells in Patients With Severe COVID-19 Pneumonia.严重 COVID-19 肺炎患者的 sCD163 和 sCD14 血浆水平升高及外周血促炎单核细胞、髓系和浆细胞样树突状细胞耗竭。
Front Immunol. 2021 Feb 26;12:627548. doi: 10.3389/fimmu.2021.627548. eCollection 2021.
6
CD169 Defines Activated CD14 Monocytes With Enhanced CD8 T Cell Activation Capacity.CD169 定义了具有增强 CD8 T 细胞激活能力的活化 CD14 单核细胞。
Front Immunol. 2021 Jul 28;12:697840. doi: 10.3389/fimmu.2021.697840. eCollection 2021.
7
Elevated circulating monocytes and monocyte activation in COVID-19 convalescent individuals.新冠肺炎康复个体中循环单核细胞升高和单核细胞活化。
Front Immunol. 2023 Apr 3;14:1151780. doi: 10.3389/fimmu.2023.1151780. eCollection 2023.
8
Comparative immune profiling of acute respiratory distress syndrome patients with or without SARS-CoV-2 infection.比较 SARS-CoV-2 感染与非感染急性呼吸窘迫综合征患者的免疫特征。
Cell Rep Med. 2021 Jun 15;2(6):100291. doi: 10.1016/j.xcrm.2021.100291. Epub 2021 May 6.
9
Kinetics of CD169, HLA-DR, and CD64 expression as predictive biomarkers of SARS-CoV2 outcome.CD169、HLA-DR和CD64表达动力学作为新冠病毒感染结果的预测生物标志物
J Anesth Analg Crit Care. 2023 Mar 27;3(1):6. doi: 10.1186/s44158-023-00090-x.
10
Along with PaO2/FiO2 ratio and lymphopenia, low HLA-DR monocytes are the only additional parameter that independently predicts the clinical course of undifferentiated SARS-CoV-2 patients in emergency departments.除了氧合指数（PaO2/FiO2）和淋巴细胞减少外，人类白细胞抗原-DR（HLA-DR）表达降低的单核细胞是唯一能独立预测急诊科未分化新型冠状病毒肺炎（SARS-CoV-2）患者临床病程的额外参数。
J Leukoc Biol. 2024 May 29;115(6):1131-1142. doi: 10.1093/jleuko/qiae022.

引用本文的文献

1
ADTnorm: robust integration of single-cell protein measurement across CITE-seq datasets.ADTnorm：跨CITE-seq数据集的单细胞蛋白质测量的稳健整合。
Nat Commun. 2025 Jul 1;16(1):5852. doi: 10.1038/s41467-025-61023-6.
2
Role of MR-proADM and Monocyte CD169 in Predicting In-Hospital and 60-Day Mortality in COVID-19 Patients.MR-proADM和单核细胞CD169在预测COVID-19患者住院及60天死亡率中的作用
Clin Pathol. 2024 Dec 16;17:2632010X241304958. doi: 10.1177/2632010X241304958. eCollection 2024 Jan-Dec.
3
ADTnorm: Robust Integration of Single-cell Protein Measurement across CITE-seq Datasets.ADTnorm：跨CITE-seq数据集的单细胞蛋白质测量的稳健整合
Res Sq. 2024 Jul 8:rs.3.rs-4572811. doi: 10.21203/rs.3.rs-4572811/v1.
4
The Dysregulation of the Monocyte-Dendritic Cell Interplay Is Associated with In-Hospital Mortality in COVID-19 Pneumonia.单核细胞与树突状细胞相互作用失调与COVID-19肺炎患者的院内死亡率相关。
J Clin Med. 2024 Apr 24;13(9):2481. doi: 10.3390/jcm13092481.
5
Kinetics of CD169, HLA-DR, and CD64 expression as predictive biomarkers of SARS-CoV2 outcome.CD169、HLA-DR和CD64表达动力学作为新冠病毒感染结果的预测生物标志物
J Anesth Analg Crit Care. 2023 Mar 27;3(1):6. doi: 10.1186/s44158-023-00090-x.
6
SARS-CoV-2 spike protein induces a differential monocyte activation that may contribute to age bias in COVID-19 severity.SARS-CoV-2 刺突蛋白诱导的单核细胞激活差异可能导致 COVID-19 严重程度的年龄偏向。
Sci Rep. 2022 Dec 2;12(1):20824. doi: 10.1038/s41598-022-25259-2.
7
Myeloid CD169/Siglec1: An immunoregulatory biomarker in viral disease.髓系CD169/唾液酸结合免疫球蛋白样凝集素1：病毒疾病中的一种免疫调节生物标志物。
Front Med (Lausanne). 2022 Sep 23;9:979373. doi: 10.3389/fmed.2022.979373. eCollection 2022.
8
Role of Siglecs in viral infections: A double-edged sword interaction.Siglecs 在病毒感染中的作用：一把双刃剑的相互作用。
Mol Aspects Med. 2023 Apr;90:101113. doi: 10.1016/j.mam.2022.101113. Epub 2022 Aug 16.
9
High CD169 Monocyte/Lymphocyte Ratio Reflects Immunophenotype Disruption and Oxygen Need in COVID-19 Patients.高CD169单核细胞/淋巴细胞比率反映了新冠病毒感染患者的免疫表型破坏和氧气需求。
Pathogens. 2021 Dec 18;10(12):1639. doi: 10.3390/pathogens10121639.
10
Altered increase in STAT1 expression and phosphorylation in severe COVID-19.严重 COVID-19 中 STAT1 表达和磷酸化的改变增加。
Eur J Immunol. 2022 Jan;52(1):138-148. doi: 10.1002/eji.202149575. Epub 2021 Nov 17.

本文引用的文献

1
Monocyte CD169 Expression as a Biomarker in the Early Diagnosis of Coronavirus Disease 2019.单核细胞 CD169 表达作为 2019 年冠状病毒病早期诊断的生物标志物。
J Infect Dis. 2021 Feb 24;223(4):562-567. doi: 10.1093/infdis/jiaa724.
2
Organizational aspects of care associated with mortality in critically ill COVID-19 patients.危重症COVID-19患者护理的组织层面与死亡率的关系
Intensive Care Med. 2021 Jan;47(1):119-121. doi: 10.1007/s00134-020-06249-2. Epub 2020 Oct 6.
3
Autoantibodies against type I IFNs in patients with life-threatening COVID-19.COVID-19 危重症患者体内针对 I 型干扰素的自身抗体。
Science. 2020 Oct 23;370(6515). doi: 10.1126/science.abd4585. Epub 2020 Sep 24.
4
Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19.血清钙卫蛋白和异常髓系细胞亚群可区分 COVID-19 重症与轻症。
Cell. 2020 Sep 17;182(6):1401-1418.e18. doi: 10.1016/j.cell.2020.08.002. Epub 2020 Aug 5.
5
Interplay between SARS-CoV-2 and the type I interferon response.SARS-CoV-2 与 I 型干扰素应答的相互作用。
PLoS Pathog. 2020 Jul 29;16(7):e1008737. doi: 10.1371/journal.ppat.1008737. eCollection 2020 Jul.
6
Early bacterial co-infection in ARDS related to COVID-19.与新型冠状病毒肺炎相关的急性呼吸窘迫综合征中的早期细菌合并感染
Intensive Care Med. 2020 Sep;46(9):1787-1789. doi: 10.1007/s00134-020-06165-5. Epub 2020 Jul 13.
7
Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.严重 COVID-19 患者的 I 型干扰素活性和炎症反应受损。
Science. 2020 Aug 7;369(6504):718-724. doi: 10.1126/science.abc6027. Epub 2020 Jul 13.
8
Coronavirus disease 2019 as a particular sepsis: a 2-week follow-up of standard immunological parameters in critically ill patients.2019冠状病毒病作为一种特殊的脓毒症：危重症患者标准免疫参数的2周随访
Intensive Care Med. 2020 Sep;46(9):1764-1765. doi: 10.1007/s00134-020-06123-1. Epub 2020 Jun 2.
9
Dysregulation of type I interferon responses in COVID-19.COVID-19 中 I 型干扰素反应失调。
Nat Rev Immunol. 2020 Jul;20(7):397-398. doi: 10.1038/s41577-020-0346-x. Epub 2020 May 26.
10
Delayed persistence of elevated monocytic MDSC associates with deleterious outcomes in septic shock: a retrospective cohort study.单核细胞源性髓系抑制细胞持续升高与脓毒性休克不良预后相关：一项回顾性队列研究
Crit Care. 2020 Apr 7;24(1):132. doi: 10.1186/s13054-020-02857-y.

COVID-19 患者入住重症监护病房时的单核细胞 CD169 表达。

Monocyte CD169 expression in COVID-19 patients upon intensive care unit admission.

机构信息

Hospices Civils de Lyon, Hôpital Edouard Herriot, Laboratoire d'Immunologie, Lyon, France.

EA 7426 Pathophysiology of Injury-Induced Immunosuppression, (Université Claude Bernard Lyon 1-Hospices Civils de Lyon-bioMérieux), Hôpital Edouard Herriot, Lyon, France.

出版信息

Cytometry A. 2021 May;99(5):466-471. doi: 10.1002/cyto.a.24315. Epub 2021 Feb 5.

DOI:10.1002/cyto.a.24315
PMID:33547747
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8014094/
Abstract

During the second surge of COVID-19 in France (fall 2020), we assessed the expression of monocyte CD169 (i.e., Siglec-1, one of the numerous IFN-stimulated genes) upon admission to intensive care units of 45 patients with RT-PCR-confirmed SARS-CoV2 pulmonary infection. Overall, CD169 expression was strongly induced on circulating monocytes of COVID-19 patients compared with healthy donors and patients with bacterial sepsis. Beyond its contribution at the emergency department, CD169 testing may be also helpful for patients' triage at the ICU to rapidly reinforce suspicion of COVID-19 etiology in patients with acute respiratory failure awaiting for PCR results for definitive diagnosis.

摘要

在法国 COVID-19 的第二次疫情高峰期（2020 年秋季），我们评估了 45 名经 RT-PCR 确诊的 SARS-CoV2 肺部感染患者入住重症监护病房时单核细胞 CD169（即 Siglec-1，众多 IFN 刺激基因之一）的表达情况。总体而言，与健康供体和细菌性败血症患者相比，COVID-19 患者循环单核细胞中 CD169 的表达被强烈诱导。除了在急诊部门的贡献外，CD169 检测对于 ICU 患者的分诊也可能有帮助，以便在等待 PCR 结果进行明确诊断的急性呼吸衰竭患者中，快速加强对 COVID-19 病因的怀疑。