Brook C W, Yeomans N D, McCarthy P G, Dudley F J, Smallwood R A
Gastroenterology Unit, Austin Hospital, Heidelberg, Vic.
Med J Aust. 1987;147(11-12):595-7.
The subsequent recurrence rate after duodenal ulcers were healed with omeprazole, 10 mg or 30 mg a day, was documented during a 12-month period in 55 patients. Endoscopy was performed if patients developed symptomatic recurrence; those patients who remained symptom-free at 12 months were also requested to undergo endoscopy to assess the incidence of asymptomatic recurrence. The proportion with symptomatic recurrence during the year was 56%. The median times (life-table analysis) to relapse were 50 and 39 weeks in the group that was treated initially with 30 mg and 10 mg of omeprazole, respectively, although this trend to slower relapse in the higher-dose group was not statistically significant. Five asymptomatic ulcers were detected in 11 asymptomatic subjects who agreed to a final endoscopy. The over-all recurrence rate was similar to previously-reported recurrence rates after the cessation of histamine H2-receptor antagonist drugs.
在55例十二指肠溃疡患者中，记录了每日服用10毫克或30毫克奥美拉唑治愈后12个月期间的后续复发率。如果患者出现症状性复发则进行内镜检查；那些在12个月时无症状的患者也被要求接受内镜检查以评估无症状复发的发生率。该年有症状复发的比例为56%。采用生命表分析，最初分别用30毫克和10毫克奥美拉唑治疗的组中，复发的中位时间分别为50周和39周，尽管高剂量组复发较慢的这一趋势无统计学意义。在11名同意最后进行内镜检查的无症状受试者中检测到5例无症状溃疡。总体复发率与先前报道的组胺H2受体拮抗剂药物停药后的复发率相似。
