Monte Junior Epifanio Silvino do, Santos Marcos Eduardo Lera Dos, Ribeiro Igor Braga, Luz Gustavo de Oliveira, Baba Elisa Ryoka, Hirsch Bruno Salomão, Funari Mateus Pereira, de Moura Eduardo Guimarães Hourneaux
Gastrointestinal Endoscopy Unit, Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.
Clin Endosc. 2020 Nov;53(6):746-749. doi: 10.5946/ce.2020.180. Epub 2020 Nov 19.
The novel coronavirus disease (COVID-19) quickly spread to all continents. However, data regarding all the signs and symptoms of COVID-19 are insufficient. Patients with COVID-19 might present higher susceptibility to fungal coinfections. Mucormycosis is a rare and often life-threatening fungal disease characterized by vascular invasion by hyphae, resulting in thrombosis and necrosis. This is the first case report of mucormycosis in a COVID-19 patient. An 86-year-old male patient was admitted to the emergency room with acute diarrhea, cough, dyspnea, and fever from 5 days prior. Blood tests revealed a hemoglobin level of 14.3 mg/dL. Five days following the admission, the patient presented with melena and a hemoglobin level of 5.6 mg/dL. A transfusion of three units of red blood cells was required. Esophagogastroduodenoscopy revealed two giant gastric ulcers with necrotic debris and a deep hemorrhagic base without active bleeding. Furthermore, biopsies confirmed mucormycosis. Despite intensive care, the patient died 36 hours after the esophagogastroduodenoscopy.
新型冠状病毒病（COVID-19）迅速蔓延至各大洲。然而，关于COVID-19所有体征和症状的数据并不充分。COVID-19患者可能更容易发生真菌合并感染。毛霉菌病是一种罕见且往往危及生命的真菌病，其特征是菌丝侵袭血管，导致血栓形成和坏死。这是首例关于COVID-19患者发生毛霉菌病的病例报告。一名86岁男性患者因5天前出现急性腹泻、咳嗽、呼吸困难和发热而被收治入急诊室。血液检查显示血红蛋白水平为14.3mg/dL。入院5天后，患者出现黑便，血红蛋白水平降至5.6mg/dL。需要输注3单位红细胞。食管胃十二指肠镜检查发现两个巨大胃溃疡，伴有坏死碎片和深部出血性基底，无活动性出血。此外，活检确诊为毛霉菌病。尽管进行了重症监护，患者在食管胃十二指肠镜检查后36小时死亡。
