Asthma UK Centre for Allergic Mechanisms in Asthma, School of Immunology and Microbial Sciences, King's College London, London SE1 9RT, United Kingdom.
Asthma UK Centre for Allergic Mechanisms in Asthma, School of Immunology and Microbial Sciences, King's College London, London SE1 9RT, United Kingdom.
Immunity. 2020 Nov 17;53(5):900-902. doi: 10.1016/j.immuni.2020.10.019.
Allergens induce type-2 immunity, but unresolved questions remain about initiation of this response. In this issue, Perner et al. propose that cutaneous activation of TRPV1 sensory neurons by protease allergens stimulates release of substance P to induce migration of Th2-skewing CD301b DC to draining lymph nodes.
过敏原会引发 2 型免疫，但关于该反应的启动仍存在一些悬而未决的问题。在本期杂志中，Perner 等人提出，蛋白酶过敏原激活皮肤中的 TRPV1 感觉神经元会刺激 P 物质的释放，从而诱导偏向 Th2 的 CD301b DC 向引流淋巴结迁移。
