First College of Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Institute of Chinese Orthopedics and Traumatology, Shandong Wendeng Osteopathic Hospital, Weihai, China.
Front Immunol. 2023 Sep 8;14:1232013. doi: 10.3389/fimmu.2023.1232013. eCollection 2023.
Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a Capermeable, non-selective cation channel that is found primarily in sensory nerve fibres. Previous studies focused on pain transmission. However, recent studies have found that the TRPV1 channel, in addition to being associated with pain, also plays a role in immune regulation and their dysregulation frequently affects the development of rheumatoid arthritis (RA). A thorough understanding of the mechanism will facilitate the design of new TRPV1-targeted drugs and improve the clinical efficacy of RA. Here, we provide an updated and comprehensive overview of how the TRPV1 channel intrinsically regulates neuronal and immune cells, and how alterations in the TRPV1 channel in synoviocytes or chondrocytes extrinsically affect angiogenesis and bone destruction. Rapid progress has been made in research targeting TRPV1 for the treatment of inflammatory arthritis, but there is still much-uncharted territory regarding the therapeutic role of RA. We present a strategy for targeting the TRPV1 channel in RA therapy, summarising the difficulties and promising advances in current research, with the aim of better understanding the role of the TRPV1 channel in RA pathology, which could accelerate the development of TRPV1-targeted modulators for the design and development of more effective RA therapies.
瞬时受体电位阳离子通道亚家族 V 成员 1（TRPV1）是一种通透、非选择性阳离子通道，主要存在于感觉神经纤维中。先前的研究主要集中在疼痛传递上。然而，最近的研究发现，TRPV1 通道除了与疼痛有关外，还在免疫调节中发挥作用，其失调经常影响类风湿关节炎（RA）的发展。深入了解其机制将有助于设计新的 TRPV1 靶向药物并提高 RA 的临床疗效。在这里，我们提供了 TRPV1 通道如何内在调节神经元和免疫细胞的最新和全面的概述，以及滑膜细胞或软骨细胞中 TRPV1 通道的改变如何外在影响血管生成和骨破坏。针对 TRPV1 治疗炎性关节炎的研究取得了快速进展，但 RA 的治疗作用仍有许多未知领域。我们提出了一种针对 RA 治疗中 TRPV1 靶点的策略，总结了当前研究中的困难和有希望的进展，旨在更好地理解 TRPV1 通道在 RA 病理中的作用，这可能会加速 TRPV1 靶向调节剂的开发，从而设计和开发更有效的 RA 治疗方法。
