Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China; Division of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou 510006, PR China.
Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Guangdong Higher Education Institutes, Department of Developmental Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, PR China.
Toxicol Appl Pharmacol. 2021 Jan 1;410:115334. doi: 10.1016/j.taap.2020.115334. Epub 2020 Nov 15.
Famciclovir (FCV) is an antiviral drug that is often utilized after bone marrow transplantation to prevent viral infection. Yet, its role in hematopoiesis is poorly understood. Here, by utilizing a zebrafish model, we found that FCV exposure led to hematopoietic failure by impairing the proliferation of hematopoietic stem and progenitor cell (HSPC) and inducing HSPC apoptosis. On the other hand, FCV treatment could effectively relieve myeloid malignancies in the c-myb MDS-like fish model, and played a role not only in the embryonic stage but also in adult zebrafish. This study reveals that FCV functions as a double-edged sword, with hematotoxicity at a high level, but that appropriate FCV treatment may be beneficial for the treatment of MDS.
泛昔洛韦（FCV）是一种抗病毒药物，常用于骨髓移植后预防病毒感染。然而，其在造血方面的作用尚未被充分了解。在这里，我们通过利用斑马鱼模型发现，FCV 暴露通过损害造血干细胞和祖细胞（HSPC）的增殖并诱导 HSPC 凋亡，导致造血衰竭。另一方面，FCV 治疗可有效缓解 c-myb MDS 样鱼模型中的髓系恶性肿瘤，并且不仅在胚胎期，而且在成年斑马鱼中都发挥作用。这项研究揭示了 FCV 是一把双刃剑，高水平的血液毒性，但适当的 FCV 治疗可能对 MDS 的治疗有益。
