SARS-CoV-2 已经取代了其他季节性呼吸道病毒：一项前瞻性队列研究的结果。

SARS-CoV-2 has displaced other seasonal respiratory viruses: Results from a prospective cohort study.

机构信息

NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust Southampton, UK; Department of Infection, University Hospital Southampton NHS Foundation Trust Southampton, UK.

Department of Infection, University Hospital Southampton NHS Foundation Trust Southampton, UK; School of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

出版信息

J Infect. 2020 Dec;81(6):966-972. doi: 10.1016/j.jinf.2020.11.010. Epub 2020 Nov 15.

DOI:10.1016/j.jinf.2020.11.010

PMID:33207254

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7666810/

Abstract

OBJECTIVES

The effect of SARS-CoV-2 on existing respiratory viruses in circulation and the overall burden of viral respiratory disease remains uncertain. Traditionally, severe viral respiratory disease disproportionally affects those with underlying chronic lung diseases. This study aimed to assess the impact of SARS-CoV-2 on the prevalence and clinical characteristics of respiratory virus disease in hospitalised adults.

METHODS

Data for this cohort study were from hospitalised adults who had multiplex PCR testing for respiratory viruses over several seasons in Hampshire, UK. Respiratory virus detection during the first epidemic peak of SARS-CoV-2 was compared to detection during the same time period across previous years.

RESULTS

856 patients had multiplex PCR for respiratory viruses between March and May over 5 years. Before 2020, a non-SARS-CoV-2 virus was detected in 54% patients (202/371) compared to 4.1% (20/485) in 2020 (p < 0.0001). SARS-CoV-2 was associated with asthma or COPD exacerbations in a smaller proportion of infected patients compared to other viruses (1.0% vs 37%, p < 0.0001).

CONCLUSIONS

The emergence of SARS-CoV-2 was associated with substantial reductions in the circulation of seasonal respiratory viruses and large differences in the characteristics of viral-associated disease, including illness in a greater proportion of patients without underlying lung disease.

摘要

目的

SARS-CoV-2 对现有循环呼吸道病毒的影响以及病毒性呼吸道疾病的总体负担仍不确定。传统上，严重的病毒性呼吸道疾病会不成比例地影响那些患有潜在慢性肺部疾病的人。本研究旨在评估 SARS-CoV-2 对住院成年患者呼吸道病毒疾病的患病率和临床特征的影响。

方法

本队列研究的数据来自英国汉普郡在多个季节住院并接受呼吸道病毒多重 PCR 检测的成年人。将 SARS-CoV-2 首次流行高峰期的呼吸道病毒检测与前几年同期的检测进行了比较。

结果

856 例患者在 5 年的 3 月至 5 月间进行了呼吸道病毒多重 PCR 检测。与 2020 年（4.1%，20/485）相比，2020 年前非 SARS-CoV-2 病毒在 54%的患者（202/371）中被检测到（p<0.0001）。与其他病毒相比，SARS-CoV-2 导致感染患者的哮喘或 COPD 恶化比例较小（1.0%比 37%，p<0.0001）。