Helgeland A, Leren P
Medical Out-Patient Clinic, Ullevaal Hospital, Oslo, Norway.
Nephron. 1987;47 Suppl 1:108-10. doi: 10.1159/000184565.
During 1972-1973, 785 symptom-free men, aged 40-49, with mild hypertension, were randomly assigned to a 5-year controlled drug treatment study, 406 in the treatment group and 379 in the control group. The basic drug was hydrochlorothiazide, in addition methyldopa or propranolol if necessary. The mean observation time was 66 months (range 60-78). At 5 years' follow-up there was no difference in total mortality between treated and controls, nor in cardiovascular mortality. There was a good prevention of cerebrovascular disease (0 vs. 7). Regarding coronary heart disease, however, there was an opposite trend (20 vs. 13, p greater than 0.10). During the trial, different drug-induced changes were observed in serum lipids, glucose and uric acid. The importance of these changes are still uncertain.
在1972年至1973年期间，785名年龄在40至49岁之间、无症状且患有轻度高血压的男性被随机分配到一项为期5年的对照药物治疗研究中，治疗组406人，对照组379人。基本药物为氢氯噻嗪，必要时加用甲基多巴或普萘洛尔。平均观察时间为66个月（范围60至78个月）。在5年随访时，治疗组和对照组的总死亡率以及心血管死亡率均无差异。对脑血管疾病有良好的预防效果（0例与7例）。然而，关于冠心病，却出现了相反的趋势（20例与13例，p大于0.10）。在试验期间，观察到血清脂质、葡萄糖和尿酸出现了不同的药物诱导变化。这些变化的重要性仍不确定。
