- 来源的银纳米粒子的抗癌和抗菌作用。
Anti-Cancer and Anti-Bacterial Effects of -Derived Silver Nanoparticles.
机构信息
Department of Biology, Ardabil Branch, Islamic Azad University, Ardabil, Iran.
Applied Stem Cell Laboratory, Medicine/Heart and Vascular Institute, Department of Medicine, The Tulane University School of Medicine, New Orleans, Louisiana, United States.
出版信息
Comb Chem High Throughput Screen. 2021;24(10):1714-1726. doi: 10.2174/1386207323999201117113401.
BACKGROUND
The use of nanoparticles has markedly increased in biomedical sciences. The silver nanoparticles (AgNPs) have been investigated for their applicability to deliver chemotherapeutic/antibacterial agents to treat cancer or infections disease. However, the existing chemical and physical methods of synthesizing AgNPs are considered inefficient, expensive and toxic.
METHODS
Natural products have emerged as viable candidates for nanoparticle production, including the use of Terfezia boudieri (T. boudieri), a member of the edible truffle family. Accordingly, our goal was to synthesize AgNPs using an aqueous extract of T. boudieri (green synthesized AgNPs). Since certain infectious agents are linked to cancer, we investigated their potential as anti-cancer and antibacterial agents.
RESULTS
The synthesis of AgNPs was confirmed by the presence of an absorption peak at 450nm by spectroscopy. The physico-chemical properties of green synthesized AgNPs were analyzed by UV-Vis, FT-IR, XRD, SEM, and TEM. In addition, their potential to inhibit cancer cell (proliferation and the growth of infectious bacteria were investigated.
CONCLUSION
The size of nanoparticles ranged between 20-30nm. They exerted significant cytotoxicity and bactericidal effects in a concentration and time-dependent manner compared to T. boudieri extract alone. Interestingly, the synthesis of smaller AgNPs was correlated with longer synthesis time and enhanced cytotoxic and bactericidal properties.
背景
纳米粒子在生物医学科学中的应用显著增加。银纳米粒子（AgNPs）已被研究用于将化疗/抗菌剂递送至治疗癌症或感染性疾病。然而，现有的化学和物理合成 AgNPs 的方法被认为效率低下、昂贵且有毒。
方法
天然产物已成为纳米粒子生产的可行候选物，包括使用 Terfezia boudieri（T. boudieri），一种可食用的块菌家族成员。因此，我们的目标是使用 T. boudieri 的水提物（绿色合成的 AgNPs）合成 AgNPs。由于某些传染性病原体与癌症有关，我们研究了它们作为抗癌和抗菌剂的潜力。
结果
通过光谱法在 450nm 处存在吸收峰证实了 AgNPs 的合成。通过 UV-Vis、FT-IR、XRD、SEM 和 TEM 分析了绿色合成的 AgNPs 的物理化学性质。此外，还研究了它们抑制癌细胞（增殖）和感染性细菌生长的潜力。
结论
纳米粒子的大小在 20-30nm 之间。与单独的 T. boudieri 提取物相比，它们以浓度和时间依赖的方式表现出显著的细胞毒性和杀菌作用。有趣的是，较小的 AgNPs 的合成与更长的合成时间以及增强的细胞毒性和杀菌特性相关。
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