- 来源的银纳米粒子的抗癌和抗菌作用。

Anti-Cancer and Anti-Bacterial Effects of -Derived Silver Nanoparticles.

机构信息

Department of Biology, Ardabil Branch, Islamic Azad University, Ardabil, Iran.

Applied Stem Cell Laboratory, Medicine/Heart and Vascular Institute, Department of Medicine, The Tulane University School of Medicine, New Orleans, Louisiana, United States.

出版信息

Comb Chem High Throughput Screen. 2021;24(10):1714-1726. doi: 10.2174/1386207323999201117113401.

DOI:10.2174/1386207323999201117113401

PMID:33208063

Abstract

BACKGROUND

The use of nanoparticles has markedly increased in biomedical sciences. The silver nanoparticles (AgNPs) have been investigated for their applicability to deliver chemotherapeutic/antibacterial agents to treat cancer or infections disease. However, the existing chemical and physical methods of synthesizing AgNPs are considered inefficient, expensive and toxic.

METHODS

Natural products have emerged as viable candidates for nanoparticle production, including the use of Terfezia boudieri (T. boudieri), a member of the edible truffle family. Accordingly, our goal was to synthesize AgNPs using an aqueous extract of T. boudieri (green synthesized AgNPs). Since certain infectious agents are linked to cancer, we investigated their potential as anti-cancer and antibacterial agents.

RESULTS

The synthesis of AgNPs was confirmed by the presence of an absorption peak at 450nm by spectroscopy. The physico-chemical properties of green synthesized AgNPs were analyzed by UV-Vis, FT-IR, XRD, SEM, and TEM. In addition, their potential to inhibit cancer cell (proliferation and the growth of infectious bacteria were investigated.

CONCLUSION

The size of nanoparticles ranged between 20-30nm. They exerted significant cytotoxicity and bactericidal effects in a concentration and time-dependent manner compared to T. boudieri extract alone. Interestingly, the synthesis of smaller AgNPs was correlated with longer synthesis time and enhanced cytotoxic and bactericidal properties.

摘要

背景

纳米粒子在生物医学科学中的应用显著增加。银纳米粒子（AgNPs）已被研究用于将化疗/抗菌剂递送至治疗癌症或感染性疾病。然而，现有的化学和物理合成 AgNPs 的方法被认为效率低下、昂贵且有毒。

方法

天然产物已成为纳米粒子生产的可行候选物，包括使用 Terfezia boudieri（T. boudieri），一种可食用的块菌家族成员。因此，我们的目标是使用 T. boudieri 的水提物（绿色合成的 AgNPs）合成 AgNPs。由于某些传染性病原体与癌症有关，我们研究了它们作为抗癌和抗菌剂的潜力。