Department of Cardiothoracic Surgery, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Neurosurgery, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Curr Protein Pept Sci. 2021;22(1):74-88. doi: 10.2174/1389203721999201117123616.
Breast cancer is a heterogeneous malignancy and is the second leading cause of mortality among women around the world. Increasing the resistance to anti-cancer drugs in breast cancer cells persuades researchers to search the novel therapeutic approaches for the treatment of this malignancy. Among the novel methods, therapeutic peptides that target and disrupt tumor cells have been of great interest. Therapeutic peptides are short amino acid monomer chains with high specificity to bind and modulate a protein interaction of interest. Several advantages of peptides, such as specific binding on tumor cells surface, low molecular weight, and low toxicity on normal cells, make the peptides appealing therapeutic agents against solid tumors, particularly breast cancer. Also, the National Institutes of Health (NIH) describes therapeutic peptides as a suitable candidate for the treatment of drug-resistant breast cancer. In this review, we attempt to review the different therapeutic peptides against breast cancer cells that can be used in the treatment and diagnosis of the malignancy. Meanwhile, we presented an overview of peptide vaccines that have been developed for the treatment of breast cancer.
乳腺癌是一种异质性恶性肿瘤，是全球女性死亡的第二大主要原因。增加乳腺癌细胞对抗癌药物的耐药性促使研究人员寻找治疗这种恶性肿瘤的新治疗方法。在新方法中，针对肿瘤细胞并破坏肿瘤细胞的治疗性肽引起了极大的关注。治疗性肽是具有高特异性与靶蛋白相互作用的短氨基酸单体链。肽具有一些优点，例如特异性结合在肿瘤细胞表面、分子量低和对正常细胞毒性低，这使得肽成为针对实体瘤，特别是乳腺癌的有吸引力的治疗剂。此外，美国国立卫生研究院 (NIH) 将治疗性肽描述为治疗耐药性乳腺癌的合适候选药物。在这篇综述中，我们试图综述针对乳腺癌细胞的不同治疗性肽，这些肽可用于治疗和诊断这种恶性肿瘤。同时，我们还概述了为治疗乳腺癌而开发的肽疫苗。
